I am running fat 650B Foss tubes with Pacenti Quasi Motos on my Rawland. That bike gets used for a 20 mile loop half-dirt half road in the East Bay hills. I've done that loop maybe a dozen times since installing the Foss tubes, so maybe a total of 300 miles, no flats yet.
I am running narrow 650B Foss tubes with Pacenti Pari Motos on my A Homer Hilsen. That bike gets used for brevets and training rides strictly on the road. I've ridden the Foss tubes for about 700 miles, and have gotten one puncture on the rear, towards the end of a 300k brevet. The peel and stick foss patch took care of it quickly.
So, in short, I don't think that a Foss tube is a $20 guarantee that you'll never ever get a puncture. It's a $20 wish that you'll be less likely to get a puncture.
I'm also evaluating tubeless to see if that gets me to never getting a flat, but I'm less than 100 miles into that experiment