Yeah, I've been doing a little more reading (particularly on the paster config files), and it seems like the ZEO doc you referenced (that was the one I was reading in the first place) is slightly misleading. For one thing, pyramid_tm handles the repoze.tm2 slot mentioned there, as well as the repoze.retry slot. It also has some automatic configuration with a tween, so the pipeline is unnecessary. For another, the example zeo.conf file it lists doesn't seem to work in my setup(win7 64 bit python 2.7), as the address part of it errors out down the callstack, saying it requires an integer. I switched it to localhost:9001 and it appears to work. The problem I'm having now is, I can't find any docs at all on zeo.conf, to see if there's anything else I should tweak in there.