I ran into this problem today as well. I'm running 10.8.3 and I've used Play 2.1.0 since it was released on this machine and on my laptop without problems.
When I started working today and saved a file (i start play with ~run but had the same problems with just run) I would see that the file was changed and recompiled in the Play console but when I reloaded the page nothing would change.
So I would get these messages:
[info] Compiling 1 Scala source to /Users/anton/Development/Code/SecretProject/target/scala-2.10/classes...
[success] Compiled in 1s
But this would not appear on reload:
--- (RELOAD) ---
[info] play - Shutdown application default Akka system.
[info] play - database [default] connected at jdbc:mysql://
127.0.0.1:3306/secret?zeroDateTimeBehavior=convertToNull[info] play - database [communication] connected at jdbc:mysql://
127.0.0.1:3306/secret[info] play - Starting application default Akka system.
[info] play - Application started (Dev)
However, every time i restarted Play (Ctrl+c) and started it again with ~run / run the page reload worked fine one time, then same problem.
I tried to run a "clean" and "clean-all", I tried deleting the target and project/target but nothing helped.
What did help was a reboot of the entire machine.
I never shutdown my machine, I always use Sleep so it is not uncommon for me to have a month uptime and I've never had this problem before.
It might have something to do with the update to 10.8.3? Beside that, I don't know what could have caused this.
I have not changed anything else in my development setup.