Extra-Low-Frequency Magnetic Fields alter Cancer Cells through Metabolic Restriction
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May 10, 2013, 11:31:29 PM5/10/13
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Attached is the full paper summarized
in Section 16 of the BioInitiative 2012 report.
(Posted by the authors on Cornell University Library's www.arxiv.org site giving open access to 843,435 e-prints in Physics,
Mathematics, Computer Science, Quantitative Biology,
Quantitative Finance and Statistics)
Extra-Low-Frequency Magnetic Fields alter Cancer
Cells through Metabolic Restriction
Ying Li1,2 and Paul Héroux1,2
1 InVitroPlus Laboratory, Department of Surgery, Royal Victoria Hospital, Montreal, Canada.
2 Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Contact: Dr. Paul Héroux, Faculty of Medicine, McGill University, Montreal, Canada,
H3A 1A3. 1-514-398-6988 paul....@mcgill.ca.
Ying Li1,2 and Paul Héroux1,2
1 InVitroPlus Laboratory, Department of Surgery, Royal Victoria Hospital, Montreal, Canada.
2 Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Contact: Dr. Paul Héroux, Faculty of Medicine, McGill University, Montreal, Canada,
H3A 1A3. 1-514-398-6988 paul....@mcgill.ca.
Abstract
BACKGROUND: Biological effects of extra-low-frequency (ELF) magnetic fields (MF) have lacked a credible mechanism of interaction between MFs and living material.
OBJECTIVES: Examine the effect of ELF-MFs on cancer cells.
METHODS: Five cancer cell lines were exposed to ELF-MFs within the range of 0.025 to 5 μT, and the cells were examined for karyotype changes after 6 days.
RESULTS: All cancer cells lines lost chromosomes from MF exposure, with a mostly flat dose-response. Constant MF exposures for three weeks allow a rising return to the baseline, unperturbed karyotypes. From this point, small MF increases or decreases are again capable of inducing karyotype contractions. Our data suggests that the karyotype contractions are caused by MF interference with mitochondria’s ATP synthase (ATPS), compensated by the action of AMP-activated protein kinase (AMPK). The effects of MFs are similar to those of the ATPS inhibitor oligomycin. They are amplified by metformin, an AMPK stimulator, and attenuated by resistin, an AMPK inhibitor. Over environmental MFs, karyotype contractions of various cancer cell lines show exceptionally wide and flat dose-responses, except for those of erythro-leukemia cells, which display a progressive rise from 0.025 to 0.4 μT.
CONCLUSIONS: The biological effects of MFs are connected to an alteration in the structure of water that impedes the flux of protons in ATPS channels. These results may be environmentally important, in view of the central roles played in human physiology by ATPS and AMPK, particularly in their links to diabetes, cancer and longevity.
Keywords: Magnetic field; Extra-Low-Frequency; ATP Synthase
Informant: André Fauteux
BACKGROUND: Biological effects of extra-low-frequency (ELF) magnetic fields (MF) have lacked a credible mechanism of interaction between MFs and living material.
OBJECTIVES: Examine the effect of ELF-MFs on cancer cells.
METHODS: Five cancer cell lines were exposed to ELF-MFs within the range of 0.025 to 5 μT, and the cells were examined for karyotype changes after 6 days.
RESULTS: All cancer cells lines lost chromosomes from MF exposure, with a mostly flat dose-response. Constant MF exposures for three weeks allow a rising return to the baseline, unperturbed karyotypes. From this point, small MF increases or decreases are again capable of inducing karyotype contractions. Our data suggests that the karyotype contractions are caused by MF interference with mitochondria’s ATP synthase (ATPS), compensated by the action of AMP-activated protein kinase (AMPK). The effects of MFs are similar to those of the ATPS inhibitor oligomycin. They are amplified by metformin, an AMPK stimulator, and attenuated by resistin, an AMPK inhibitor. Over environmental MFs, karyotype contractions of various cancer cell lines show exceptionally wide and flat dose-responses, except for those of erythro-leukemia cells, which display a progressive rise from 0.025 to 0.4 μT.
CONCLUSIONS: The biological effects of MFs are connected to an alteration in the structure of water that impedes the flux of protons in ATPS channels. These results may be environmentally important, in view of the central roles played in human physiology by ATPS and AMPK, particularly in their links to diabetes, cancer and longevity.
Keywords: Magnetic field; Extra-Low-Frequency; ATP Synthase
Informant: André Fauteux
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