Jason,
Lucee 5 isn't ready for production, and from the bit of manual testing I've done, you may run into more issues with functionality that has been moved to extensions than with core language features. Micha is working through them tho' as they are reported.
That said, depending on your codebase, you may also run into a few incompatibilities in the migration from ACF to Lucee 4.5. For instance, I ran into an issue with typing in a QofQ where I was using a decimal notation in a varchar, sort of like a dewey decimal number, and Lucee converted that into a numeric in the QofQ instead of leaving it as a varchar, and then 23.3 became equivalent to 23.30 and 23.300 in Lucee when they were not equivalent in ACF. Small corner case that I simply worked around.
PDFs created from cfdocument also behave differently in that the PDF engine that Lucee uses does not use the page dimensions set in the cfdocument tag for scaling purposes in the same way as ACF. You'll need to wrap the layout within the cfdocument tag in a div tag that specifies the page dimension.
Another issue you might run across is that Lucee prefers you use cfloop for grouping nested queries as syntactically correct, rather than the somewhat quirky <cfoutput query="myquery" group="mycolumn"> syntax.
So on a practical basis, I'd suggest working through any compatibility issues you run into on 4.5, which is production ready, and then any testing you can do on 5, once you have your codebase working on 4.5, would be greatly appreciated.
Nando