Fwd: Postdoc in Bioinformatics - Heinrich Heine University Duesseldorf
Tal Galili
From: Ran Elkon <ra...@tauex.tau.ac.il>
Date: Tue, May 30, 2017 at 2:21 PM
Subject: Postdoc in Bioinformatics - Heinrich Heine University Duesseldorf
To: TAU-B...@listserv.tau.ac.il
The Department of Pediatric Oncology, Hematology and Clinical Immunology (Head: Prof. Dr. A. Borkhardt) at the Center for Child and Adolescent Health (Heinrich Heine University Duesseldorf / Germany) is looking for a highly motivated
Postdoc in Bioinformatics / Computational Biology
The position is immediately available with an appointment for three years with the possibility of an extension.
Description
We, the Department of Pediatric Oncology, Hematology and Clinical Immunology (Head: Prof. Dr. A. Borkhardt) at Heinrich Heine University Duesseldorf / Germany, perform integrative data analysis of complex sequencing-derived datasets.
Our group is performing an ongoing prospective study on cancer predisposition syndromes (CPSs) - termed `Germline mutations in children with cancer´ - in a cohort of children with a newly diagnosed malignancy by trio whole-exome sequencing (WES) of the affected children and their parents. The study aims to determine the proportion of children affected by a well-known or suspected underlying CPS and to gain new insights into the inheritance and pathogenesis of childhood cancer. Shortly, the study will be expanded to additional pediatric oncology centers in Germany and, thus, get a multicenter approach.
A bioinformatics pipeline has already been established in close collaboration with the Institute of Medical Informatics (Head: Prof. Dr. M. Dugas), Muenster, and need to be continuously updated. In silico analysis can be conducted in collaboration with the Department of Biochemistry, Bioinformatics (Prof. Dr. H. Sticht). In addition, in close contact with the Dugas group, we aim to address further bioinformatics research questions, e.g. pathway analysis, de novo mutations, and mosaicism, which specifically address the unique potential of the trio approach.
Our department hosts a sequencing core facility and participates in further sequencing studies on cancer research. We support other groups in the preparation, execution and analysis of large-scale sequencing data and are actively involved in various international collaborations.
We are seeking a postdoctoral fellow to perform integrative analysis on Trio WES datasets, which are both already available in our group and will continuously be generated using state-of-the-art techniques. This also includes uncommon data such as trios from affected children and their parents. The integrative analysis of multiple of these datasets allows a deeper and more complex understanding of the pathogenesis of cancer in childhood.
References
Fremerey et al. Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome. FAME 2016
Kuhlen et al. Cancer susceptibility syndromes in children in the area of broad clinical use of massive parallel sequencing. EJP 2015
Schwartzman et al. Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. PNAS 2017
Your profile:
· PhD in bioinformatics, computational biology, or computer science (or equivalent experience)
· Excellent oral and written communication skills in English
· Knowledge of German is not a prerequisite but an advantage
· Good understanding of molecular and cancer biology
· Experience in the analysis of next generation sequencing data
· Use existing as well as develop new methods and tools for handling, analyzing and interpreting sequencing data
· Working experience with UNIX-like operating systems including HPC environments
· Programming skills with scripting languages such as Perl, Python or Bash scripting
· Solid knowledge in statistics and R programming
· Experience with bayesian models and/or network modeling is a plus
· Ability to work independently while collaborating and assisting the team in its common research goals
We offer:
· Highly interesting position in an interdisciplinary setting
· Nationwide unique dataset
· Participation in leading national and international research consortia
· Participation in national and international conferences
· Stimulating research environment
· Training options (iGRAD)
· Attractive surroundings; Duesseldorf is an attractive city with the media harbor and the old town. Given its large university, it has a lively student as well as cultural scene (Deutsche Oper am Rhein, Kommoedchen, several festivals over the year, Fortuna Duesseldorf). Duesseldorf is based at the heart of the lively Rhein-Ruhr metropolitan region, the largest metropolitan region in Germany with over 11 million inhabitants.
Salaries will be based on TV-L guidelines (TV-L E13). Part-time work is theoretically also an option.
Handicapped applicants with equal qualifications will be employed preferentially. The Heinrich-Heine-University encourages women to apply. Women with equal qualifications will be employed preferentially.
For questions regarding the position, please contact Michael...@med.uni-duesseldorf.de.
Please submit your application within four weeks of the appearance of this offer containing a letter of motivation, CV, description of scientific experience and the addresses of two referees electronically to:
Prof. Dr. Arndt Borkhardt / PD Dr. Michaela Kuhlen
Department of Pediatric Oncology, Hematology and Clinical Immunology
Center for Child and Adolescent Health
Heinrich Heine University
Moorenstrasse 5, 40225 Duesseldorf
Germany
Arnd.Bo...@med.uni-duesseldorf.de / Michael...@med.uni-duesseldorf.de