I presume by uibinder owner you mean your HelloWorld class overrides the onEvent() method, is that correct?
I also presume that you have some other component that is using the HelloWorld objects and attaching them to the view.
For example, in your EntryPoint:
HelloWorld h1 = new HelloWorld();
HelloWorld h2 = new HelloWorld();
FlowPanel panel = new FlowPanel();
panel.add(h1);
panel.add(h2);
GWT.getRoot().add(panel);
If you want to "destroy" h1, and have it stop reacting to events, simply remove it from the dom and ensure it is garbage collected (ie. set your reference to null):
panel.remove(h1);
h1 = null;