CouchDB is meant to be used RESTfully, so go ahead and create those POST requests. That said, there are several Django backends that will help you to communicate
with CouchDB but this might be more trouble than it's worth. It all depends on what you need from CouchDB. Personally I'd forego any wrappers and just use it directly. You sacrifice some of the flexibility and power of CouchDB by hiding behind Django's RDBMS-centric backend.
If you're worried about security, which is really only an issue if you choose to expose the CouchDB server to the Internet, then go ahead and look into the various authentication options offered by CouchDB. However, if it's just eavesdropping you're worried about, you can configure your CouchDB server to use SSL and limit its connections to those originating from your server only.