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Iron Depletion Improves Glycemic Control
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ironjustice
May 6, 2020, 8:43:41 AM5/6/20
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Iron Depletion Improves Glycemic Control in Poorly Controlled Type 2 Diabetic Patients with Iron Overload and Negative Main HFE-Gene Mutations
JDM> Vol.5 No.3, August 2015 PP. 164-172
DOI: 10.4236/jdm.2015.53020
A. Mahmoud1*, Adel A. Elazab Elged2, Rasha A. Elgamal2, Abdelhady M. Hamada2
1Internal Medicine Department, Ain-Shams University, Cairo, Egypt.
2Clinical Pathology Department, Ain-Shams University, Cairo, Egypt.
ABSTRACT
Iron overload increases the risk of diabetes via mechanisms of abnormal glucose metabolism: insulin deficiency, insulin resistance, and/or hepatic dysfunction. Iron reduction upregulates glucose uptake and improves hepatocytes insulin receptor activity. This study was conducted to examine the effects of iron depletion—via controlled phlebotomy—on the hypoglycemic treatment in poorly controlled type 2 diabetes mellitus (T2DM) patients with non-genetic iron overload. Forty three patients with poorly controlled T2DM and iron overload were divided into 2 groups: iron depletion group and control group. Regular phlebotomy was performed for iron depletion group on monthly basis until serum ferritin reached 20 μg/L or less. Both groups were examined and compared for blood pressure, serum ferritin, lipid profile, HFE-gene, HbA1c, HOMA-IR and number of medicines used for diabetic control. The results had revealed that group differences of HbA1c (-2.64, 95% CI -3.23 to 2.04, p < 0.001) and HOMA-IR (-0.68, 95% CI -0.98 to -0.37, p < 0.001) showed significant decreases in iron depletion group at end of study. Significant decrease in the numbers of hypoglycemic medicines in iron depletion group was shown at end of study (p < 0.001); 66.7% of iron depletion group patients were receiving 1 or 2 medicines at end of studyversus none of the control group. Diastolic blood pressure (DBP), triglycerides and LDL-C decreased significantly while HDL-C levels showed significant rise after iron depletion. It can be concluded from the present study that iron depletion therapy is beneficial for improving the efficiency of glycemic control, DBP, and dyslipidemia in poorly controlled type 2 diabetics with iron over load.
KEYWORDS
Iron Overload, Poorly Controlled Diabetes, Phlebotomy, Hypertension, Dyslipidemia
Cite this paper
Mahmoud, A. , Elged, A. , Elgamal, R. and Hamada, A. (2015) Iron Depletion Improves Glycemic Control in Poorly Controlled Type 2 Diabetic Patients with Iron Overload and Negative Main HFE-Gene Mutations. Journal of Diabetes Mellitus, 5, 164-172. doi: 10.4236/jdm.2015.53020.
https://www.scirp.org/journal/paperinformation.aspx?paperid=58429
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JDM> Vol.5 No.3, August 2015 PP. 164-172
DOI: 10.4236/jdm.2015.53020
A. Mahmoud1*, Adel A. Elazab Elged2, Rasha A. Elgamal2, Abdelhady M. Hamada2
1Internal Medicine Department, Ain-Shams University, Cairo, Egypt.
2Clinical Pathology Department, Ain-Shams University, Cairo, Egypt.
ABSTRACT
Iron overload increases the risk of diabetes via mechanisms of abnormal glucose metabolism: insulin deficiency, insulin resistance, and/or hepatic dysfunction. Iron reduction upregulates glucose uptake and improves hepatocytes insulin receptor activity. This study was conducted to examine the effects of iron depletion—via controlled phlebotomy—on the hypoglycemic treatment in poorly controlled type 2 diabetes mellitus (T2DM) patients with non-genetic iron overload. Forty three patients with poorly controlled T2DM and iron overload were divided into 2 groups: iron depletion group and control group. Regular phlebotomy was performed for iron depletion group on monthly basis until serum ferritin reached 20 μg/L or less. Both groups were examined and compared for blood pressure, serum ferritin, lipid profile, HFE-gene, HbA1c, HOMA-IR and number of medicines used for diabetic control. The results had revealed that group differences of HbA1c (-2.64, 95% CI -3.23 to 2.04, p < 0.001) and HOMA-IR (-0.68, 95% CI -0.98 to -0.37, p < 0.001) showed significant decreases in iron depletion group at end of study. Significant decrease in the numbers of hypoglycemic medicines in iron depletion group was shown at end of study (p < 0.001); 66.7% of iron depletion group patients were receiving 1 or 2 medicines at end of studyversus none of the control group. Diastolic blood pressure (DBP), triglycerides and LDL-C decreased significantly while HDL-C levels showed significant rise after iron depletion. It can be concluded from the present study that iron depletion therapy is beneficial for improving the efficiency of glycemic control, DBP, and dyslipidemia in poorly controlled type 2 diabetics with iron over load.
KEYWORDS
Iron Overload, Poorly Controlled Diabetes, Phlebotomy, Hypertension, Dyslipidemia
Cite this paper
Mahmoud, A. , Elged, A. , Elgamal, R. and Hamada, A. (2015) Iron Depletion Improves Glycemic Control in Poorly Controlled Type 2 Diabetic Patients with Iron Overload and Negative Main HFE-Gene Mutations. Journal of Diabetes Mellitus, 5, 164-172. doi: 10.4236/jdm.2015.53020.
https://www.scirp.org/journal/paperinformation.aspx?paperid=58429
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
col...@gmail.com
May 8, 2020, 2:43:25 PM5/8/20
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I avoid iron as much as I can and take 3 things 2 chelate it from my body.
%
May 8, 2020, 4:31:45 PM5/8/20
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On 2020-05-08 11:43 a.m., col...@gmail.com wrote:
> I avoid iron as much as I can and take 3 things 2 chelate it from my body.
>
you test when you know you'll get a low reading and then try to show off
> I avoid iron as much as I can and take 3 things 2 chelate it from my body.
>
how good you're doing
col...@gmail.com
May 8, 2020, 5:59:44 PM5/8/20
to
I test when I except to get the highest bg.
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