Hi,
I recently used Internet Explorer on a Windows Vista machine and found several issues with Alt-F web pages, such as tooltips not showing-up, bookmarks not working, and several other issues, some of then affecting Alt-F working.
I promptly installed Firefox, Chrome, Safari and Opera, and none of the problems I noticed with IE showed-up.
So, for majority of reason (80%!), IE should not be used with Alt-F web pages.
Notice that I'm not saying that IE is a piece of #%"!, and that my poor lame web pages are the greatest, I'm only saying that you should not use it with Alt-F. No flames, please!
Take care and enjoy
João
PS: I develop Alt-F using Firefox on a linux box.