TODAY: Barocas, 23-Apr-2024, 12:20pm Central
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Ellad Tadmor
Apr 23, 2024, 11:31:05 AMApr 23
to aem-solid...@umn.edu
AEM Mechanics Research Seminar
Tuesday 23-Apr-2024, 12:20pm Central
Prof. Victor Barocas
Department of Biomedical Engineering, University of Minnesota
Title: Fiber-level remodeling rules drive realistic tissue-level arterial modeling in silico
Abstract: The complex mechanical behavior of arteries has long been studied for combination of axial stretch and pressurization. Notably, when the ends of the vessel are capped during the test, the force on the end caps can rise, fall, or stay flat with increasing pressure depending on the amount of imposed stretch. Some 40 years ago, the observation was made that the axial stretch at which the force vs. pressure (FP) curve is flat is very close to the in vivo stretch of the vessel. Although teleological arguments have been put forward, no mechanism has been proposed for the artery to sense the end force. We have recently found that such sensing may not be necessary because the remodeling of individual fibers within a computationally modeled artery leads to the observed effect with no macroscopic feedback. Rather, the combination of tissue architecture and microscopic remodeling rules results in a vessel whose macroscopic FP curve is flattest at an axial stretch roughly equal to the in vivo stretch. Our results suggest that it is not that the in vivo stretch is the one at which the FP curve is flat, but that for a given in vivo stretch, the artery remodels itself so that the FP curve is flat, based solely on local, microscale remodeling rules. The seminar will discuss the problem, our model, our results, and the further questions that they raise.
For more information, visit the AEM Mechanics Research Seminar website:
Tuesday 23-Apr-2024, 12:20pm Central
In-person: Room 321, Mechanical Engineering, University of Minnesota
Online: Webinar registration link
Department of Biomedical Engineering, University of Minnesota
Title: Fiber-level remodeling rules drive realistic tissue-level arterial modeling in silico
Abstract: The complex mechanical behavior of arteries has long been studied for combination of axial stretch and pressurization. Notably, when the ends of the vessel are capped during the test, the force on the end caps can rise, fall, or stay flat with increasing pressure depending on the amount of imposed stretch. Some 40 years ago, the observation was made that the axial stretch at which the force vs. pressure (FP) curve is flat is very close to the in vivo stretch of the vessel. Although teleological arguments have been put forward, no mechanism has been proposed for the artery to sense the end force. We have recently found that such sensing may not be necessary because the remodeling of individual fibers within a computationally modeled artery leads to the observed effect with no macroscopic feedback. Rather, the combination of tissue architecture and microscopic remodeling rules results in a vessel whose macroscopic FP curve is flattest at an axial stretch roughly equal to the in vivo stretch. Our results suggest that it is not that the in vivo stretch is the one at which the FP curve is flat, but that for a given in vivo stretch, the artery remodels itself so that the FP curve is flat, based solely on local, microscale remodeling rules. The seminar will discuss the problem, our model, our results, and the further questions that they raise.
For more information, visit the AEM Mechanics Research Seminar website:
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Ellad B. Tadmor, Ph.D.
Russell J. Penrose Professor
Department of Aerospace Engineering and Mechanics
University of Minnesota
https://dept.aem.umn.edu/~tadmor/
Russell J. Penrose Professor
Department of Aerospace Engineering and Mechanics
University of Minnesota
https://dept.aem.umn.edu/~tadmor/
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