TODAY: Robert Tranquillo, 02-Jul-24, 12:20pm Central
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Ellad Tadmor
Jul 2, 2024, 9:21:20 AM (18 hours ago) Jul 2
to aem-solid...@umn.edu
AEM Mechanics Research Seminar
Tuesday 02-Jul-2024, 12:20pm Central
Prof. Robert Tranquillo
Distinguished McKnight University Professor, Depts. of BME and CEMS, University of Minnesota
Title: Biologically-Engineered Heart Valves that Grow
Abstract: We have developed a biologically-engineered tube of cell-produced collagenous matrix, which is allogeneic upon a decellularization performed prior to implantation and thus “off-the-shelf.” It is grown from dermal fibroblasts entrapped in a sacrificial fibrin hydrogel tube that is then decellularized using sequential detergent treatments. The resulting cell-produced matrix tube possesses physiological strength, compliance, and alignment (circumferential). Using the concept of a tubular heart valve, where the tube collapses inward with back-pressure between 3 equi-spaced constraints placed around the periphery to create one-way valve action, we have created a set of novel heart valves for adults and children that offer indefinite durability and growth potential because the matrix becomes a living tissue with the recipient’s cells post-implantation as shown in multiple growing lamb studies. A robust FEM-based algorithm based on an anisotropic hyperelastic constitutive model was implemented for in silico construction of the novel tri-tube heart valve was developed to facilitate optimization of the leaflet geometry with respect to coaptation area, solid stress, and pinwheel index resulting from simulated closure from applied back-pressure. Preliminary FSI results are also presented.
For more information, visit the AEM Mechanics Research Seminar website:
Tuesday 02-Jul-2024, 12:20pm Central
In-person: Room 321, Mechanical Engineering, University of Minnesota
Online: Webinar registration link
Distinguished McKnight University Professor, Depts. of BME and CEMS, University of Minnesota
Title: Biologically-Engineered Heart Valves that Grow
Abstract: We have developed a biologically-engineered tube of cell-produced collagenous matrix, which is allogeneic upon a decellularization performed prior to implantation and thus “off-the-shelf.” It is grown from dermal fibroblasts entrapped in a sacrificial fibrin hydrogel tube that is then decellularized using sequential detergent treatments. The resulting cell-produced matrix tube possesses physiological strength, compliance, and alignment (circumferential). Using the concept of a tubular heart valve, where the tube collapses inward with back-pressure between 3 equi-spaced constraints placed around the periphery to create one-way valve action, we have created a set of novel heart valves for adults and children that offer indefinite durability and growth potential because the matrix becomes a living tissue with the recipient’s cells post-implantation as shown in multiple growing lamb studies. A robust FEM-based algorithm based on an anisotropic hyperelastic constitutive model was implemented for in silico construction of the novel tri-tube heart valve was developed to facilitate optimization of the leaflet geometry with respect to coaptation area, solid stress, and pinwheel index resulting from simulated closure from applied back-pressure. Preliminary FSI results are also presented.
For more information, visit the AEM Mechanics Research Seminar website:
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Ellad B. Tadmor, Ph.D.
Russell J. Penrose Professor
Department of Aerospace Engineering and Mechanics
University of Minnesota
https://dept.aem.umn.edu/~tadmor/
Russell J. Penrose Professor
Department of Aerospace Engineering and Mechanics
University of Minnesota
https://dept.aem.umn.edu/~tadmor/
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