Postdoc positions Hsiung Lab UCSF (CRISPR/gene regulation/immuno-oncology/tissue injury repsonse)

[Daly, Meagan]

Dear Students, 

The Hsiung Lab (www.hsiunglab.org) at UCSF is recruiting exceptionally capable postdoctoral

researchers. We are molecular genetics and synthetic biology enthusiasts interested in

understanding and engineering emergent properties of genetic elements. We recently

developed a functional genomics platform and screen compression framework for exploring

higher-order combinatorial genetic perturbations using engineered CRISPR-Cas12a (Hsiung et

al., Nature Biotechnology, 2024).

The postdoctoral candidate will have opportunities to develop and/or apply cutting-edge CRISPR

synthetic biology and functional genomics approaches in several areas:

1. Enhancer biology and epigenetics

2. Tissue injury responses, including fibrosis and regeneration

3. Novel models of human tissue biology from surgical specimens

4. Therapeutic cell reprogramming

5. Genetic screens focused on emergent properties of tissues, with emphasis on cell-cell

interactions and spatially resolved readouts

6. Engineering cancer cells to be recognized by the immune system

We particularly welcome candidates with knowledge and skills in some of these areas: singlecell and/or spatial genomics, immunology/immuno-oncology, genome regulation, liver

biology, computational biology, and experience with mouse models. For appropriate projects

the candidate may have the opportunity to work collaboratively with junior specialists in the

lab.

Please contact Chris Hsiung at Chris....@ucsf.edu with your CV, a statement of your interest

in the lab, potential start date, and contact information for 2-3 references