Postdoc opportunity at Jain Lab at UCSF/Gladstone, working on oxygen/vitamin metabolism

[Daly, Meagan]

The Jain Lab (https://ishajainlab.com) at UCSF/Gladstone is looking for motivated, hard-working and curious applicants. At a high level, we study how organisms interact with their environments – how “what we breathe” and “what we eat” affects our metabolism and disease progression. More specifically, we are focused on oxygen and vitamin/cofactor metabolism. We recently discovered that chronic hypoxia (equivalent to living in the mountains of Peru or Nepal) can serve as a therapy for mitochondrial disease. This approach is currently in clinical trials. This work has inspired a broader set of research directions ranging from fundamental biochemistry to animal physiology.

The questions we ask:

1. How do cells and organisms sense oxygen or vitamin levels? Are there novel oxygen sensors and vitamin sensors to be found?

2. How does the body adapt to variations in oxygen levels? Or vitamin levels?

3. When the supply and demand of oxygen or vitamins becomes mismatched, how does this contribute to disease?

4. Can we “turn the oxygen and vitamin dials” into creative new therapies?

5. What is the most practical form of turning these concepts into translatable therapies?

The approach we take: CRISPR screens, metabolomics, classical biochemistry/molecular biology, animal physiology and beyond.

Post-docs will be encouraged to lead independent projects resulting in high impact publications, present at conferences and prepare for long-term careers in academia or industry.

Please email Isha...@gladstone.ucsf.edu for more info or to apply.

Best, 

Emma Straight (she/her/hers)
Administrative Assistant

Office of Isha Jain, PhD

Gladstone Institutes Cardiovascular Disease

Core Support: 

Genomics Core, Histology & Light Microscopy Core, Stem Cell Core, Transgenic Core

emma.s...@gladstone.ucsf.edu

(415) 734-2705

Gladstone Institutes

Science Overcoming Disease
gladstone.org
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