Hi,
My knowledge on WRF-Hydro is limited, however, I will share my general experience and I am open to any comments.
1. Change in domain size or resolution= need to redo spin-up(s), unless you manually resample/modify those restart files to match new domain (which is impractical).
2. Physics options = It depends on which option you are changing. In many cases, model itself will run using restart files that were generated from previous spin-up(s) that has minor difference in physics option. However, when doing so, WRF-Hydro may take some time stabilizing soil/gw/snow/etc storage, and model simulation may not yield the most reliable results in those early periods.
I hope it helps.
Best,
Donny