From what I understand, you want to modulate some synthesis parameters of a music system which sonifies data in real time. Sonification is an interesting topic in the field of generative art and computer music or whatnot. There are many articles on specific projects dealing with this but maybe a collection that compiles lots of essays can be found at The Sonification Handbook, by Hermann and others.
From my experience, in terms of practical issues of mapping strategies you may try what’s working for you and the musical objectives of your project. Some ideas might come from trying to implement a one to one mapping or one to many, the latter having the benefit of letting also a set of parameters to interact with each other. That said, range specs will be one of the main things you may experiment the most since not all synthesis parameters share the same optimal range, that is amplitude vs frequency etc. One of the ideas that I have found to be working is the dynamic adjustment of these specs using other approaches such as live coding and on the fly arrangement of the mapping implementation.
Other than that, mapping is one of the really interesting questions in the field of interactive music but with more than one answers which are answered by hearing the results and constantly modifying until something musically meaningful pops out.
Hope that helps a bit.