46 or 48 chromosomes in neanderthal?

[bo....@telia.com]

Hi, Dr Bo Falk from Sweden.

Just for now I only want to now the chromosme number in Neandethal, Denisovan, and Sasquat bigfoot.

Best!

Bo Falk

Agricultural ecologist.

[Robert Kuhn]

Hello, Bo,

That's a good question.  The DNA from which sequence is obtained from Neandertal

and Denisovan is far too degraded to make a guess about the number of chromosomes.

There is no credible bigfoot.

I presume your interest stems from the knowledge that chimp has an extra pair of

chroms compared to human?  The fusion of two chimp chroms (now called chr2A and

chr2B -- formerly chr12 and chr13 when named in order of size) into chr2 of human 

happened some time after the two species diverged, but the timing of this event is 

hard to nail down.

Here is a Browser session that shows chimp sequence aligned to the region of the q-arm

of human chr2 where the second centromere appears to have been inactivated by 

rearrangement after the fusion.  The human DNA on either side of this region is homologous

to regions flanking the centromere of chimp chr2B.

http://genome.ucsc.edu/cgi-bin/hgTracks?hgS_doOtherUser=submit&hgS_otherUserName=Example&hgS_otherUserSessionName=hg19_chr2chimpNeander

Note that the Neandertal coverage in the region shows some regions of poor alignment 

quality in the rearranged regions.  I do not know how to interpret that.  If I had to guess,

I'd take the significant amount of Neandertal sequence found in modern humans as

evidence that the two had little difficulty interbreeding so they likely had the same

number of chroms.  But don't quote me ;--).

best regards,

     --b0b kuhn

    ucsc genome bioinformatics group

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