[genome-announce] New GENCODE "knownGene" V48 for human (hg38/hg19) and VM37 for mouse (mm39)

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Jairo Navarro Gonzalez

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May 19, 2025, 6:36:56 PMMay 19
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Hello everyone,

We are pleased to announce the release of the GENCODE Genes V48 for human (hg38/GRCh38 & hg19/GRCh37) and the GENCODE Genes VM37 for mouse (mm39/GRCm39). The GENCODE "knownGene" V48 and VM37 gene tracks were built using a UCSC pipeline (knownGene) and the GENCODE comprehensive gene set to generate high-quality manual annotations merged with evidence-based automated annotations. The GENCODE "knownGene" tracks are our default gene tracks, which have extensive associations to external sources. This allows for additional metadata on every item as well as external links. The track description pages contain options for configuring the display, such as showing non-coding genes, splice variants, and pseudogenes.

Below is a summary of the contents found in each release. For more details, visit the GENCODE site.

GENCODE v48 Release Stats
GenesObservedTranscriptsObserved
Protein-coding genes19,435Protein-coding transcripts89,843
Long non-coding RNA genes35,901- full length protein-coding65,024
Small non-coding RNA genes7,563- partial length protein-coding24,819
Pseudogenes14,695Nonsense mediated decay transcripts21,902
Immunoglobulin/T-cell receptor gene segments649Long non-coding RNA loci transcripts191,076
Total No of distinct translations65,814Genes that have more than one distinct translations13,646

GENCODE VM37 Release Stats
GenesObservedTranscriptsObserved
Protein-coding genes21,529Protein-coding transcripts58,636
Long non-coding RNA genes36,111- full length protein-coding45,038
Small non-coding RNA genes6,105- partial length protein-coding13,598
Pseudogenes13,790Nonsense mediated decay transcripts7,247
Immunoglobulin/T-cell receptor gene segments701Long non-coding RNA loci transcripts155,932
Total No of distinct translations44,964Genes that have more than one distinct translations10,850

We would like to thank the GENCODE project for providing these annotations.


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