[genome-announce] Bionano DLE-1 CTTAAG sites for human, hg38 and hg19

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Jairo Navarro Gonzalez

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Jul 23, 2025, 6:47:42 PMJul 23
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Hello everyone,

We are happy to announce the release of the Bionano DLE-1 track for human assemblies hg38 and hg19. These tracks show the CTTAAG sites used by the Bionano Optical Genome Mapping system, an assay to detect structural variants.

OGM (Optical Genome Mapping) begins with the isolation of ultra-high molecular weight (UHMW) DNA from blood, bone marrow aspirates, cultured cells (including chorionic villi and amniocytes), tissue, or tumor biopsies. A single enzymatic reaction places fluorescent labels throughout the genome at a specific sequence motif. The labeled DNA molecules are linearized in nanochannel arrays on the chip. Changes in the patterning or spacing of the labels are identified by software solutions to detect all classes of structural variants accurately. The OGM data generated can be analyzed alone, or in combination with sequencing or array data.


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