New gnomAD Mutation Constraint Track

[Daniel Schmelter]

Hello DNA people,

We have just released the GnomAD Genomes Mutation Constraint track on the human GRCh38/hg38 genome assembly. This track's data is based on GnomAD v3.1.2 and shows the relative frequency of variation in 1 kilobase windows across the entire genome. This quantifies the population occurrence of disruptive variation caused by purifying natural selection. This is similar to negative selection on loss-of-function (LoF) for genes but calculated for non-coding regions too. View the complete set of GnomAD tracks and read more on the GnomAD description page.

All the best,

Daniel Schmelter

UCSC Genome Browser; UCSC Genomics Institute
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