New gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track for hg19

[Gerardo Perez]

Hello Everyone,

We are happy to announce the release of the gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track for hg19, now available in the gnomAD superTrack. This track shows a score that tries to identify missense-depleted regions using the patterns of rare missense variation in 125,748 gnomAD v2.1.1 exomes, compared to a null mutational model. Missense-depleted regions are enriched for ClinVar pathogenic variants, de novo missense variants in individuals with neurodevelopmental disorders (NDDs), and complex trait heritability. This track can be used to aid in interpreting missense variants.

Transcript regions with constraint predictions are colored using the viridis palette, where yellow indicates the lowest OE values and dark blue-purple indicates the highest.

A corresponding MPC version for hg38 is planned for release by the gnomAD team in 2026.

We would like to thank Kaitlin Samocha for suggesting this track and the Genome Aggregation Database Consortium (gnomAD) for making the data available.