[genome-announce] Unusually Conserved Regions track for hg38

[Jairo Navarro Gonzalez]

Hello everyone,

We are happy to announce the release of the Unusually Conserved Regions track for GRCh38/hg38. The supertrack consists of 12 tracks that show regions of unusual conservation in humans relative to other organisms. The full list of tracks, along with item count and coverage, is summarized in the following table:

Track	Count	Coverage in bp
HAQERS: Human Ancestor Quickly Evolved Regions	1,580	1,410,669
HARs: Human Accelerated Regions (HARs) merged from various publications by the Pollard Lab	2,647	681,420
Long hConDels: Long Human Conserved Deletions - present in chimp and macaque but deleted in humans	583	293,809
Short hConDels: Human Conserved Deletions < 40bp	10,032	1,968,123
UCNEBase Chicken - Chicken-conserved elements	4,351	1,415,142
UCNEBase Paralogs - Paralogous elements	987	215,800
UCNEBase Clusters: Ultra-conserved genomic regulatory blocks	239	199,269,634
Ultracons: Ultraconserved regions - 100% identical in human, mouse, and rat, >200bp	481	126,007
UltraZoos: Ultraconserved regions in Zoonomia alignment - 100% identical in 235 species, >20bp	4,552	131,661
ZooHARs: Human Accelerated Regions (HARs) from Zoonomia alignments	312	49,173
Zoonomia RoCCs: Runs of contiguous phyloP constraint	595,536	26,995,284
Zoonomia UNICORNs: Unannotated Intergenic Constrained Regions	423,586	16,155,520

We want to thank Katie Pollard, Hiram Clawson, James Xue, Matt Christmas, Carol Nguyen, and Mark Diekhans for providing the data. We would also like to thank Max Haeussler and Jairo Navarro for the creation and release of the tracks.

Jairo Navarro 
UCSC Genome Browser
UC Santa Cruz Genomics Institute
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