[genome-announce] MaveDB Experiment Heatmaps and Alignment track for hg38

[Jairo Navarro Gonzalez]

Hello everyone,

We are excited to announce the release of the MaveDB Experiment Heatmaps and Alignment track for hg38. This release provides heatmaps of multiplexed assays of variant effects (MAVE) from MaveDB. Each heatmap presents the results of an experiment where many small substitutions were tested within a gene to examine their functional consequences. Accompanying tracks display alignments of each experiment sequence to the genome.

Please note that only a subset of MaveDB experiments could be displayed as heatmaps; the sequence alignments in this track only cover those experiments.

Genome Browser screenshot of BRCA1 exon 19 showing the alignment and heatmap tracks.

Hover over each item in the heatmap to see the consequence of substituting individual amino acids within the genome with alternatives. Score ranges vary among experiments, but each is presented with the highest scores in red, the lowest scores in blue, and scores at the midpoint between the two in silver. Higher scores correspond to a higher enrichment level for that variant compared to others in the experiment set.

We would like to thank Jeremy Arbesfeld and the MaveDB team for making this data publicly available. We would also like to thank Melissa Cline, Jonathan Casper, and Jairo Navarro for the creation and release of the Genome Browser tracks.