[genome-announce] MANE select v1.0 track available for hg38

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Jairo Navarro Gonzalez

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Feb 25, 2022, 7:06:31 PMFeb 25
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Hello everyone,

We are happy to announce the release of the MANE select v1.0 track for the human (GRCh38/hg38) assembly. The Matched Annotation from NCBI and EMBL-EBI (MANE) project aims to produce a matched set of high-confidence transcripts that are identically annotated between RefSeq (NCBI) and Ensembl/GENCODE (led by EMBL-EBI). Transcripts for MANE are chosen by a combination of automated and manual methods based on conservation, expression levels, clinical significance, and other factors.

Note that MANE v1.0 is a beta release and only covers 89% of protein-coding genes. RefSeq and Ensembl will continue to develop this single transcript gene set and provide comprehensive sets of alternate transcripts in the RefSeq-All and the GENCODE tracks.

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