New public hub: UniversalEPI ENCODE

[Gerardo Perez]

Hello Everyone,

We are pleased to announce the release of a new Public Hub, UniversalEPI ENCODE for hg38. This track hub displays normalized ATAC-seq and Hi-C interaction predictions based on ENCODE data and generated using UniversalEPI. UniversalEPI is an attention-based deep ensemble model that predicts enhancer–promoter interactions (EPIs) up to 2 Mb apart using only DNA sequence and chromatin accessibility (ATAC-seq) data. The hub contains two composite tracks:

• Hi-C Predictions - This composite track displays Hi-C interaction predictions generated by UniversalEPI using normalized ATAC-seq data from ENCODE cell lines and primary cells as input. Two tracks are provided per input ATAC-seq dataset: one log-transformed ICE-normalized Hi-C track and one z-score Hi-C track.

• Normalized ATAC-seq - This composite track shows the normalized ATAC-seq data used as input for UniversalEPI to predict Hi-C interactions. The data is derived from ENCODE cell lines and primary cells, offering a broad view of chromatin accessibility across various cell types.

We would like to thank the Boeva Lab at ETH Zurich for creating this hub.