Updates to gnomAD variation track (GRCh37/hg19)(GRCh38/hg38)

[Gerardo Perez]

Hello Everyone,

We are pleased to announce updates to the gnomAD Variants super-track for the hg19/GRCh37 and hg38/GRCh38 human assemblies.

• gnomAD v3.1 is now available and contains variants from 76,156 whole genomes (and no exomes), all mapped to the GRCh38/hg38 reference sequence. 4,454 genomes were added to the number of genomes in the previous v3 release. For more detailed information on gnomAD v3.1, see the related blog post.
• The latest release (gnomAD 2.1.1) is also available for GRCh37/hg19 genome assembly. This release contains variant data for 125,748 exomes and 15,708 whole genomes.
• Three filters are now available for our updated v2.1.1 (GRCh37/hg19) and gnomAD v3.1 (GRCh38/hg38) tracks, by minor allele frequency (MAF), quality tags, annotation type, and variant type.
• Mouse hover over now displays details about each variant, including the affected gene(s), the variant type, and annotation.
• Following the conventions on the gnomAD browser, items are shaded according to their Annotation type: pLoF is red, Missense is orange, Synonymous is green, and Others are black.

We would like to thank the Genome Aggregation Database (gnomAD) team at the BROAD institute and the UCSC Genome Browser team members Christopher Lee, Anna Benet-Pages, Daniel Schmelter, and Gerardo Perez for developing and releasing these tracks.