SpliceAI Wildtype tracks for hg38

[Gerardo Perez]

Hello Everyone,

We are pleased to announce the release of the SpliceAI Wildtype tracks for hg38, available in the Splicing Impact superTrack. These tracks show the scores for the genome sequence itself, without variants, from predicted splice donor (5' intron boundaries) and splice acceptor (3' intron boundaries) sites. Predictions are strand-specific, with separate subtracks for the plus and minus strands.

• SpliceAI Acceptor Plus – Splice acceptor sites, plus strand
• SpliceAI Acceptor Minus – Splice acceptor sites, minus strand
• SpliceAI Donor Plus – Splice donor sites, plus strand
• SpliceAI Donor Minus – Splice donor sites, minus strand

These tracks are useful in combination with the variants track for evaluating new transcript models. They can be used to assess potential exon boundaries or possible splice acceptor sites.

We would like to thank Illumina for making SpliceAI available, both the model and the precomputed data files. Thanks to Francois Lecoquierre from the University of Oxford, Jean-Madeleine de Sainte Agathe from Institut Pasteur Paris, and Michael Hiller from the Senckenberg Museum Frankfurt for suggesting and then creating the SpliceAI Wildtype annotations.