A Genome Browser look at 2025 and support over the holidays

[Gerardo Perez]

Hello Everyone,

We hope everybody has had a productive and successful year. As we approach the end of 2025, we would like to thank our users for their continued interest in the Genome Browser and inform everyone about our limited availability during the upcoming holidays.

The UCSC campus will be closed from Monday, December 22, 2025, through Friday, January 2, 2026. During this time, we will be monitoring the mailing lists for urgent messages, but many questions may go unanswered until early January. Below is a list of available resources in case anyone needs assistance.

• General Genome Browser questions: gen...@soe.ucsc.edu

• Private list (not publicly archived or searchable) for questions containing sensitive information: genom...@soe.ucsc.edu

• Questions regarding setting up a mirror site or troubleshooting an existing mirror site: genome...@soe.ucsc.edu

You may find the answer to your question in our archived mailing list forums:

• Google Group forum: https://groups.google.com/a/soe.ucsc.edu/forum/#!forum/genome

• Google Group Mirror site forum: https://groups.google.com/a/soe.ucsc.edu/forum/#!forum/genome-mirror

You could also do a Genome Browser search, which includes results in our help docs and public hubs.

Note: AI assistants can also provide accurate UCSC support and often parse and present our documentation more concisely. If you find yourself digging through forums or Genome Browser search results, we encourage you to try asking an AI first, as it is often faster and provides correct answers to many common questions.

Here are some Genome Browser releases you may have missed in 2025:

• UCSC Genome Browser celebrated its 25th anniversary on July 7, 2025

• Our latest publication, which also includes a summary of our year

• 4 new public hubs

• New Genome Browser tutorials with interactive walkthroughs

• New highlight features for track hubs

• New bedMethyl and bigMethyl track type

• New Exon Relevance Recommended Track Set

• Over 30 new or updated tracks for human and mouse, including:

• Latest GENCODE gene models for hg19/hg38/mm39

• COSMIC v101 for hg38 and hg19

• Clinical Interpretation of Variants in Cancer (CIViC) track for hg38 and hg19

• enGenome VarChat track for hg38 and hg19

• Splicing Impact Prediction Scores super track: SpliceVarDB and SpliceAI Wildtype tracks for hg38

• MITOMAP track for hg38 and hg19

• Pseudogenes track for hg38

• VISTA Enhancers track update for Human and Mouse

• gnomAD pext track for hg38 and gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track for hg19

• Varaico variants track for hg38 and hg19

• Unusually Conserved Regions track for hg38

• ENCODE4 Long-read RNA-seq Transcripts for hg38 and mm10

• Pathogenicity prediction scores: MutScore (hg19/hg38)

• and M-CAP (hg19)

• Capture long-seq (CLS) long-read lncRNAs tracks for hg38 and mm10

• MaveDB Experiment Heatmaps and Alignment track for hg38

• EVA SNP release 7 for 40 assemblies

• And much more!

Thank you again for your continued support. We strive to provide the best tool for our users and always want to hear how we can improve. If you have any suggestions you would like to submit to the Genome Browser, such as novel datasets we could adopt or features you would like to see, you may do so here: http://genome.ucsc.edu/cgi-bin/hgUserSuggestion

Happy holidays!

 - The Browser Team