ridiculously easy question I can never remember

[Holly H. Hobart]

I have never burned into my brain the exact meaning of the ‘arrows’ shown on the lines indicating the length of DNA strands in the browser display.  They indicate directionality, but is it 5’ -> 3’ or 3’ -> 5’?  My gut feeling is that it is 5’ -> 3’, the direction of synthesis in transcription.

 

So if I look at the display for the gene KMT2A, the arrows indicate motion from left to right, so the ‘right ‘side of the gen on the screen is the 3’ end of the gene. no?

 

I know I should have a firmer grip on this concept, I just don’t.

 

thanks for answering what should be a trivial question,

 

HHH

 

Holly H Hobart, PhD, Dipl. ABMGG

Clinical Cytogenetics Lab, UMMC

(601) 984-1903

 

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[Robert Kuhn]

Hello, H3,

Your intuition is correct:  The arrows indicate the direction of transcription

and translation.

regards,

 --b0b kuhn

   ucsc genome bioinformatics group

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[Bert Gold]

Yes, KMT2A is left to right, 5' to 3' although my eyes are getting really bad at seeing the arrows.

Bert

Bert Gold, MB(ASCP)CM, Ph.D., FACMGG, CGMBS  

Senior Clinical Molecular Geneticist

Natera, Inc.

201 Industrial Rd

San Carlos, California

EMAIL: bg...@natera.com

OFFICE: (650) 249-9090 extension 1537

CELL: (302) 507-1827

On Fri, Jun 9, 2017 at 12:42 PM, Holly H. Hobart <hho...@umc.edu> wrote:

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