Fwd: PhD position: Polygenic adaptation in Groningen
Filip Kolar
PHD
POSITION IN GENOMICS OF POLYGENIC ADAPTATION
Groningen Institute for Evolutionary Life Sciences
(GEFLIES), Univ. of Groningen, The Netherlands
A fully-funded PhD position is available in the Chan Lab
to work on projects related to tracking selection
response in pedigrees at the haplotype level, with the
aim of understanding the how rapid polygenic selection
in a population genetics and quantitative genetics
framework, with the possibility of a double-degree
option with Prof. David FIELD at Macquarie University,
Sydney, Australia (more below).
We're looking for a PhD student with a population and/or
statistical genetics background to take on the analysis
of a number of large population datasets. Our group has
recently developed haplotagging, a "linked-read"
sequencing technique that extends Illumina sequencing
with haplotype long-read information. We have a number
of datasets ranging from mice (both artificially
selected like "Longshanks" mice and wild island mice),
humans, birds, flowering plants, fishes and more. We are
interested in detecting the signatures of (polygenic)
selection response and developing and using new
concepts, e.g., large-scale ancestral recombination
graphs (ARGs) in characterising the selected loci and
haplotypes.
You will work in close coordination with Prof. Nick
BARTON (IST Austria) and/or Prof. Gerton LUNTER (Univ.
Medical Centre Groningen). Our overarching goal is to
link theory with empirical genomic data. The ideal
candidates will have a strong background in
bioinformatics, including experience with genomic data
analysis and strong quantitative and programming skills.
Further background in population genetics and modelling
will be an advantage.
Among the projects on offer, there is an attractive
option to pursue a cotutelle/double-degree together with
our partner laboratories and/or Universities such as
with Prof. David FIELD at Macquarie University in
Sydney, Australia.
You will enjoy excellent computational and sequencing
support, as well as the opportunity to design and
conduct functional tests in mice together with our
wet-bench team members.
GELIFES at the University of Groningen, the Netherlands
is a unique institute dedicated to evolutionary biology.
Its members' research covers the span from ecosystems
through organismal biology to neurobehaviour. Our group
members enjoy close interactions with the labs of
Felicity JONES (molecular genetics of adaptations in
sticklebacks) and Leo BEUKEBOOM (sex determination
systems). The Chan Lab is embedded in a network of
researchers with multiple ERC-funded projects from
within GELIFES, in Groningen and beyond. We have access
to state-of-the-art research and computational
facilities. All seminars and communications are in
English.
Groningen is vibrant and lively; it is the youngest city
in the Netherlands. It ranks among the highest for
living standards, happiness and student satisfaction.
For informal enquiries and applications (cover letter,
CV, and two reference contacts), please e-mail frank...@rug.nl.
Consideration of applications will begin on 31 Dec, 2024
and remain open until the position is filled, with a
target start date in March 2025.
--
Czech Academy of Sciences
252 43 Pruhonice, Czech Republic