Titration

[Dinko Rekic]

I asked Devin this directly before I discovered the google_group. 

Basically, I want to change the dose for a drug based on the drug's concentration. Here is some code that does not work but illustrates what I want to do. 

Ideally I would like the titration to be dependent on TIME and CONC as well. Any suggestions are appreciated. 

Many thanks and Kind regards..Dinko

##------------------------------------------------------------------------------------------------------------------------------------------------------------------------

code <- '

$PARAM TVCL = 1.3, TVVC=28, TVKA=0.6, WT=70, F1=1

$SET delta=0.1

$CMT GUT CENT

$MAIN

// ... why does not this work? 

 _F(1) = F1;

if(CENT>0.1) _F(1) = F1*0.1;

//if(CENT>0.1 && TIME>48) _F(1) = F1*0.1;

double CLi = exp(log(TVCL) + 0.75*log(WT/70) + ETA(1));

double VCi = exp(log(TVVC) + ETA(2));

double KAi = exp(log(TVKA) + ETA(3));

$OMEGA name="IIV"

0.1 0 0

$ODE

dxdt_GUT = -KAi*GUT;

dxdt_CENT = KAi*GUT - (CLi/VCi)*CENT;

$TABLE

table(CP) = CENT/VCi;

table(ETA1) = ETA(1);

table(ETA2) = ETA(2);

$CAPTURE  ETA(1) ETA(2)  _F(1)

'

##------------------------------------------------------------------------------------------------------------------------------------------------------------------------

[Devin Pastoor]

discussing with kyle....

the short answer is 'problem' is in the addl locks the dosing records (this was to try to mimic nonmem's behavior.

please post this to github as we're trying to use github as much as possible over this group so we can track issues and make them more easily discoverable for new people. 

I can post a work around on github

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[Kyle Baron]

Dinko - 

Please do stop by github if you an find the time.  I'd like to work on this with you to get a convenient implementation for dynamic dosing like this.

https://github.com/metrumresearchgroup/mrgsolve/issues/240

Thanks,

Kyle

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Kyle Baron, PharmD, PhD

Senior Scientist
Metrum Research Group