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mrgsolve

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Google group for discussion of mrgsolve.

mrgsolve is an R package maintained under the auspices of Metrum Research Group, LLC, that facilitates simulation from models based on systems of ordinary differential equations (ODE) that are typically employed for understanding pharmacokinetics, pharmacodynamics, and systems biology and pharmacology.

Visit http://www.metrumrg.com/opensourcetools.html to obtain mrgsolve and find help with getting started with mrgsolve
mrgsolve ACoP6 poster
mrgsolve on GitHub: https://github.com/metrumresearchgroup/mrgsolve
mrgsolve issue tracker: https://github.com/metrumresearchgroup/mrgsolve/issues

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6/15/22

Running a posted simulation

I am a new user and I have been trying to run the code located at: Chapter 11 Topics | mrgsolve User

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Running a posted simulation

I am a new user and I have been trying to run the code located at: Chapter 11 Topics | mrgsolve User

6/15/22

9/8/19

a quesiton of mrgsolve:::nmxml

Hi Kyle, I noticed that some XML files from nonmem ouptut have "nm:" as the starting

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a quesiton of mrgsolve:::nmxml

Hi Kyle, I noticed that some XML files from nonmem ouptut have "nm:" as the starting

9/8/19

Dinko Rekic, Kyle Baron2

1/24/18

bsv and zero order absorbtion

Hi Dinko - See the code below. I followed your example of parameterizing this with from DUR. In that

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bsv and zero order absorbtion

Hi Dinko - See the code below. I followed your example of parameterizing this with from DUR. In that

1/24/18

liru...@gmail.com, Kyle Baron3

12/20/17

A naive question: does mrgsolve include an optimization/estimation function

Hi Kyle, Thank you for the feedback! The link for poster seems to be broken ... could you provide

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A naive question: does mrgsolve include an optimization/estimation function

Hi Kyle, Thank you for the feedback! The link for poster seems to be broken ... could you provide

12/20/17

10/3/17

Accounting for time-varying covariates on PK parameters in mrgsolve

Attached is a demo example of a simple 1 compartment first-order absorption model to illustrate the

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Accounting for time-varying covariates on PK parameters in mrgsolve

Attached is a demo example of a simple 1 compartment first-order absorption model to illustrate the

10/3/17

jscav...@gmail.com, Kyle Baron4

9/18/17

trouble with mread() while following "introduction.pdf" for 2016-03-12 workshop

Hi James - Then it sounds like the call should be model <- mread("intro_model") If

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trouble with mread() while following "introduction.pdf" for 2016-03-12 workshop

Hi James - Then it sounds like the call should be model <- mread("intro_model") If

9/18/17

Dinko Rekic, … Kyle Baron3

6/16/17

Dinko - Please do stop by github if you an find the time. I'd like to work on this with you to

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Dinko - Please do stop by github if you an find the time. I'd like to work on this with you to

6/16/17

kri...@gmail.com, … Devin Pastoor7

6/2/17

Include condition based on simulation time

Krina, Also - one drug, one model. Differences in routes of dosing should not impact the model

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Include condition based on simulation time

Krina, Also - one drug, one model. Differences in routes of dosing should not impact the model

6/2/17

kyleb, … Anna Olsén15

4/17/17

Requesting feedback and testers for Windows platform

Anna - Please let me know if we can help with anything. GitHub is the preferred location these days:

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Requesting feedback and testers for Windows platform

Anna - Please let me know if we can help with anything. GitHub is the preferred location these days:

4/17/17

Jon Collins, Kyle Baron2

11/4/16

Is there a way to resimulate epsilons

Jon - Here is an example for resimulating EPS values: https://github.com/metrumresearchgroup/mrgsolve

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Is there a way to resimulate epsilons

Jon - Here is an example for resimulating EPS values: https://github.com/metrumresearchgroup/mrgsolve

11/4/16

Indy Sandaradura, Kyle Baron3

9/6/16

Mac installation & GFortran 6.1

I just saw that you posted the same issue on Github. Let's keep the conversation going there and

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Mac installation & GFortran 6.1

I just saw that you posted the same issue on Github. Let's keep the conversation going there and

9/6/16

Kyle Baron, Yaming Su3

8/11/16

Request: help with compiler test on Windows

Thank you, Yaming! On Thu, Aug 11, 2016 at 9:35 AM, Yaming Su <yami...@gmail.com> wrote: Kyle

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Request: help with compiler test on Windows

Thank you, Yaming! On Thu, Aug 11, 2016 at 9:35 AM, Yaming Su <yami...@gmail.com> wrote: Kyle

8/11/16

Yaming Su, Kyle Baron5

8/5/16

doParallel in Windows

You might see a warning like this: 2: In file.remove(so) : cannot remove file 'C:/Users/MetrumRG/

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doParallel in Windows

You might see a warning like this: 2: In file.remove(so) : cannot remove file 'C:/Users/MetrumRG/

8/5/16

7/28/16

Important mrgsolve issue (with fix)

Please see this important issue: https://github.com/metrumresearchgroup/mrgsolve/issues/96 And the

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Important mrgsolve issue (with fix)

Please see this important issue: https://github.com/metrumresearchgroup/mrgsolve/issues/96 And the

7/28/16

yami...@gmail.com, … Kyle Baron9

7/18/16

implement an interidividual variability in the residual variance

Thanks for trying it. I think that NONMEM prevents you from calculating C2 in $DES and then accessing

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implement an interidividual variability in the residual variance

Thanks for trying it. I think that NONMEM prevents you from calculating C2 in $DES and then accessing

7/18/16

yami...@gmail.com, Kyle Baron5

7/11/16

mread failed but mcode worked

This is (was) a bug. https://github.com/metrumresearchgroup/mrgsolve/issues/71 I bumped the version

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mread failed but mcode worked

This is (was) a bug. https://github.com/metrumresearchgroup/mrgsolve/issues/71 I bumped the version

7/11/16

Jae Eun Ahn, Kyle Baron5

5/17/16

way to account for empirical PK dose nonlinearity in user-defined model

One more thing ... not about the original question (Jae Eun: you probably are already aware of this;

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way to account for empirical PK dose nonlinearity in user-defined model

One more thing ... not about the original question (Jae Eun: you probably are already aware of this;

5/17/16

Andre, Kyle Baron2

5/13/16

Hi Andre - There is an installation guide here: https://github.com/metrumresearchgroup/mrgsolve/wiki/

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Hi Andre - There is an installation guide here: https://github.com/metrumresearchgroup/mrgsolve/wiki/

5/13/16

4/6/16

mrgsolve 0.5.12

mrgsolve 0.5.12 is release on our github site. This release contains important bug fixes and some new

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mrgsolve 0.5.12

mrgsolve 0.5.12 is release on our github site. This release contains important bug fixes and some new

4/6/16

Kyle Baron, Devin Pastoor2

3/16/16

FWD: R-SIG-Mac Installing source package/altering fortran location

Hmm next time I reformat my mac I will be sure to carefully exactly what I've done, though I don

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FWD: R-SIG-Mac Installing source package/altering fortran location

Hmm next time I reformat my mac I will be sure to carefully exactly what I've done, though I don

3/16/16

3/15/16

March 12 2016 workshop slides

We did a free mrgsolve workshop last weekend in San Diego. The slides were posted here: https://

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March 12 2016 workshop slides

We did a free mrgsolve workshop last weekend in San Diego. The slides were posted here: https://

3/15/16

Kyle Baron, Devin Pastoor10

3/4/16

Randomness with mrgsolve

Here is the proposed solution to using mclapply with mrgsolve in a shiny app: https://gist.github.com

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Randomness with mrgsolve

Here is the proposed solution to using mclapply with mrgsolve in a shiny app: https://gist.github.com

3/4/16

3/2/16

Setting initial conditions

I was helping someone off the list with the process for initial conditions. I posted the vignette

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Setting initial conditions

I was helping someone off the list with the process for initial conditions. I posted the vignette

3/2/16

mct941, Kyle Baron4

3/1/16

compiling errors when running example

Max - You can have R do this automagically when it start up. It takes a little time, but read this:

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compiling errors when running example

Max - You can have R do this automagically when it start up. It takes a little time, but read this:

3/1/16

3/1/16

mrgsolve v0.5.11

https://github.com/metrumresearchgroup/mrgsolve/releases/tag/v0.5.11 Please upgrade if using 0.5.001

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mrgsolve v0.5.11

https://github.com/metrumresearchgroup/mrgsolve/releases/tag/v0.5.11 Please upgrade if using 0.5.001

3/1/16

2/25/16

Updating parameters when included on the first record of a (sparse) data set

Another issue with 0.5.001 https://github.com/metrumresearchgroup/mrgsolve/issues/6 This has been

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Updating parameters when included on the first record of a (sparse) data set

Another issue with 0.5.001 https://github.com/metrumresearchgroup/mrgsolve/issues/6 This has been

2/25/16

2/15/16

Absorption lag time via time-varying KA

A user asked about this off the list. I wrote it up and posted here: http://kylebmetrum.github.io/

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Absorption lag time via time-varying KA

A user asked about this off the list. I wrote it up and posted here: http://kylebmetrum.github.io/

2/15/16

2/12/16

mrgsolve on GitHub

We're rolling out a GitHub for mrgsolve today: https://github.com/metrumresearchgroup/mrgsolve We

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mrgsolve on GitHub

We're rolling out a GitHub for mrgsolve today: https://github.com/metrumresearchgroup/mrgsolve We

2/12/16

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