Hello,
I have a reference strain already within IMG/ER and from which we assembled three additional genomes of closely related strains, with high degree of synteny among the strains. The strains have an average pairwise similarity of ~97%.
We would like to conduct some comparative genomic analysis and we have spent some time to manually curate the annotation of the reference strain. Would you recommend to do "de novo" annotations with these newly assembled genomes through IMG/ER, or is there a way to build on top of the annotation of the reference strain within the system?
Thank you for your time,
Kevin