The Sixth Critical Assessment of protein Function Annotation

[Iddo Friedberg]

Dear all,

CAFA 6, the Sixth Critical Assessment of protein Function Annotation, is now live on Kaggle, with $50,000 in total prize money.

https://www.kaggle.com/competitions/cafa-6-protein-function-prediction

The problem: There are many proteins in the databases for which the sequence is known, but the function is not. The gap between what we know and what we do not know is growing. A major challenge in the field of bioinformatics is to predict the function of a protein from its sequence or structure. At the same time, how can we judge how well these function prediction algorithms are performing?

The solution: The Critical Assessment of protein Function Annotation algorithms (CAFA) is an experiment designed to provide a large-scale assessment of computational methods dedicated to predicting protein function, using a time challenge. Briefly, CAFA organizers provide a large number of protein sequences. The predictors then predict the function of these proteins by associating them with Gene Ontology terms.

Happy predictions!

Iddo Friedberg, on behalf of the CAFA 6 organizers

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Iddo Friedberg

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