Simulating a zero-order absorption model

[Catalina Barceló Campomar]

Good morning,

I am using IQReventTable() to create an eventTable with individual PK and PD parameters and then simulate individual PK and PD profiles with sim_IQRmodel. I just wanted to confirm I am using the arguments correctly.

The model has a zero-order absorption, drug dose goes into ADM=1 and we also have a Tlag1. Am I correct to indicate it like this?

 

eventTable <- IQReventTable(eventData, regression = paraNames, abs0inputs=c(1), abs0Tk0param=c("Tk0"))

 

Should I indicate somewhere that we also have  a Tlag1?

Without abs0inputs and abs0Tk0param, is it correct that since Tinf is not adjusted then an IV bolus is assumed ?

 

Many thanks in advance for your help,

Catalina