HCP-D children data normalization

[Vadim Axelrod]

Dear list,

To the best of my understanding, the minimally processing pipeline of HCP-D is similar to HCP-YA. So, the data is brought to MNI (adult) space. If so, how acceptable is it to normalize a child brain (especially very young such as 8 yo) to an adult template? I wonder because there are suggestions that pediatric atlases might be beneficial. 

Many thanks,

Vadim

[Glasser, Matt]

Volume-based registration is inherently very inaccurate for most of the brain, so I wouldn’t be relying on that for anything critical in the cortex.  Morphometrics are all measured in individuals’ space.  I guess it would be good to know the usecase where you think this would make a substantial difference.

 

Matt.

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[Vadim Axelrod]

Thank you for your answer! 

Indeed, papers which suggested using pediatric atlases indeed use volume-based analysis.

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[Glasser, Matt]

Improvements on the surface and then again when using multimodal information will swamp those issues (e.g., Coalson et al., 2018 PNAS).

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