PDC 1.0 Release on Perturbation of Treatment-Resistant Depression
Elam, Jennifer
News from the Connectome Coordination Facility (CCF)
April 27, 2023
The
Perturbation of Treatment-Resistant Depression Connectome by Fast-Acting Therapies disease project is happy to announce its 1.0 release of imaging and behavioral data on the NIMH
Data Archive (NDA,
DOI:
10.15154/1528673).
Perturbation of the Depression Connectome (PDC) is a study of adults with and without treatment resistant depression (191 patients, 51 controls) and with and without fast-acting
treatment interventions (ages 20-64, with treatment-resistant depression treated with ECT [N=44], ketamine [N=67], or total sleep deprivation [N=60], plus healthy controls [N=51]).
Of the healthy controls, 16 underwent total sleep deprivation and 17 were assessed at 2 visits without intervention.
The PDC study is sharing a rich dataset of brain, clinical, and cognitive/neuropsychological measures from these adult subjects.
PDC Release 1.0 data includes:
- unprocessed data of all modalities (structural MRI, resting state fMRI, task fMRI for 3 tasks, and diffusion MRI) for 227 subjects
- minimally preprocessed MRI data of all modalities for up to 218 subjects
- clinical and behavioral data for 230 subjects
Want more information? Check out the PDC Release 1.0 Reference Manual and other documentation to help with understanding the project and interpreting the data.
Get Access and Download the data: Get started with the Data Access and Download Instructions for obtaining access, navigating NDA and using it's download tools. We've also created a wiki that details setup steps for downloading data via NDA's command line tools.
The released data are available on NDA as:
- PDCRec package of recommended preprocessed + behavioral data (1076 GB, OPTION ONE)
- PDCAllFiles package of all released imaging and behavioral data (9.5 TB, OPTION ONE)
- PDCImgManifestBeh package of imaging manifests + behavioral data (332 MB, OPTION ONE)
- or can be filtered on to create a custom package of a subset of the data (OPTION TWO).
Join the Community. If
you are actively using HCP data and tools, we encourage you to join and be active in the HCP-Users
Google group, so that you can tune in to technical discussions on issues that may be of interest. Once
you have joined (posts from nonmembers are moderated to control spam), post questions to hcp-...@humanconnectome.org.
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