Hi Ken,
If you have HTTPS enabled on the Guest Collection, users can view or download files via their browser. That works well in some cases where the end users don’t want to (or can’t) install something like Globus Connect Personal. Of course, the data still moves, it’s just going over HTTPS to the end user’s device.
If neuroglancer can read files over HTTPS, then you might be able to make this work. The issue will be handling the access token from the application. That can be done in various ways, and the level of effort will depend on the application.
—Rick