In the past I've been able to use --user-data-dir=${HOME}/attempt1 , 2, 3, etc. to get a Chrome instance with the field trial disabled where a bug didn't repro. Then do a diff on the hashes in chrome://version to narrow it down.
Depending on the way the trial is configured
--disable-features=FooBar,BarBaz,...
or (typically for older things) something like
--force-fieldtrials=SiteIsolationExtensions/Enabled/
--force-fieldtrials=SiteIsolationExtensions/Control/
should force something on/off. But "Enabled" or "Control" could be other strings as well. E.g. "Enabled_Dogfood".