TL;DR: OOPIFs are now possible in M55 on Win/Mac/Linux/ChromeOS, for isolating web content from extensions. They are also enabled for 50% of M54 Beta users.
In case you haven't seen it in our OOPIF status emails,
we have enabled --isolate-extensions mode by default in M55. This means that Chrome will use
out-of-process iframes (OOPIFs) to put web iframes in a separate process from an extension parent frame, and vice versa. This affects Windows, Mac, Linux, and ChromeOS, but not yet Android. 50% of M54 Beta users on these platforms also have this mode enabled.
This is a big step forward for security, and it represents the first uses of OOPIFs after a long effort to update Chrome's architecture and features. Our team is continuing to update features and fix bugs as we prepare to use OOPIFs for more use cases, including GuestViews (e.g., <webview>) evaluating --top-document-isolation mode, and ultimately
Site Isolation.
If you've been putting off work to update your feature to handle OOPIFs, now is the time. :) Our Site Isolation team is happy to help guide you with the things we've learned so far.
Charlie Reis and the Site Isolation Team
(Also posted to chromium-dev)