It's hard to predict whether "is" will make it into the standard.
Nobody is working on removing "is" right now.
If "is" isn't implemented by other browsers, here's typically what would happen:
2. When use drops below a certain level, usually around 0.03% of page views, we would discuss removing "is" on blink-dev and start to print a deprecation message on the devtools console when a page uses "is". There's absolutely no guarantee about this 0.03% level, by the way, it is just a guide. It may be much higher (if there are extenuating circumstances like the availability of a different, standards-based API for the same purpose) or lower (if we're working on other stuff that is higher priority.)
3. In the some subsequent version of Chrome (maybe the very next one) we would stop processing the "is" attribute.
Hopefully you can use this to inform your own decision about whether to use "is".