Hi everyone,
As part of the 'AI for the Life Sciences' webinar series (see email below), I wanted to share details about our next speaker, which may be of particular interest to the single-cell community.
Speaker: Stefano Mangiola, Group Leader, South Australian Immunogenomics Cancer Institute
Title: 'Improving the interpretability of AI models for cell biology and precision medicine'
Abstract:
The Human Cell Atlas (HCA), with its millions of single-cell profiles, combined with advances in AI, has enabled the development of foundational models that capture complex biological principles—from cell states to regulatory dynamics. These models excel at tasks such as cell typing, batch correction, and predicting gene perturbation outcomes, yet their capacity to expose the biological patterns they learn—such as lineage hierarchies, disease-driving interactions, or microenvironmental cues—remains largely unexplored. While existing models achieve high predictive accuracy, their interpretability—the ability to trace predictions to biologically meaningful features like gene modules, or regulatory networks—is often an afterthought. This opacity limits their utility for mechanistic discovery, stifling collaboration between computational and experimental researchers who require actionable, testable insights. Our research group is dedicated to systematically evaluating and improving the interpretability of AI models in single-cell biology.
Time and Date: 12-1 pm AEST, Tuesday, August 26
I hope to see you there!
All my best,
Giorgia