Another couple of papers to contribution looking at CD4+ T-cell interactions with antigen and antigen presenting cells

[mtp_69_i]

Some more paper reading has brought two papers from 2009 to my
attention. Not sure if these have been discussed previously so I
thought I'd put them up.

http://www.ncbi.nlm.nih.gov/pubmed/19930039

Characterization of CD4+ T-cell–dendritic cell interactions during
secondary antigen exposure in tolerance and priming

Rush CM, Millington OR, Hutchison S, Bryson K, Brewer JM, Garside P.

Immunology. 2009 Dec;128(4):463-71.

and

http://www.ncbi.nlm.nih.gov/pubmed/19699173

Dynamics of T Cell, Antigen-Presenting Cell, and Pathogen Interactions
during Recall Responses in the Lymph Node

Chtanova T, Han SJ, Schaeffer M, van Dooren GG, Herzmark P, Striepen
B, Robey EA.

Immunity. 2009 Aug 21;31(2):342-55.

Both of these papers use live cell imaging to examine memory T-cell
(CD4+) responses to antigen, pathogens and antigen presenting cells.

The results of the first paper show CD4+ T-cells behave differently in
their interactions with antigen presenting cells depending on whether
they have been previously exposed to a given antigen (ie primed or
tolerised compared to naive). These differences indicate primed CD4+
T-cells interact more intensely with antigen presenting cells compared
to naive, while tolerised CD4+ T-cells interact less.

The second paper shows very nicely how following challenge with
antigen from Toxoplasma gondii, primed CD4+ T-cells (memory T-cells)
migrated faster than naive T-cells, relocalised to the site of
infection and engaged in prolonged interactions with infected cells
(macrophages in this case).

I thought these papers might be of interest to those in this
discussion group who feel there is a lack of hard evidence that
antigen stimulation of the immune system leads to demonstrable changes
in immune system behaviour that results in outcomes such as immunity
to specific diseases and immune responses that are protective against
death from the "constant presence of pathogens".

[JC]

So, in other words, they support the concept of immunisation by
producing memory cells. How interesting.

John

[Peter McCarthy]

Yeah, but it goes further than that I think. They show (literally) that these cells respond to the challenge and actively engage in behaviour consistent with their description as cells that help to protect the body from disease.

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