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Challenge: Where is the Evidence in Evidence-based Medicine?
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PeterB
Jun 19, 2009, 11:30:06 PM6/19/09
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This challenge to our resident “skeptics” is designed to demonstrate
that confidence in evidence based medicine is based largely on a
theoretical benefit rather than risk-adjusted health outcomes in real
people. This is roughly the tenth time or so I have published the
challenge without a single taker. If you choose to respond, you
should state the number of deaths per 1000 (or fraction thereof)
associated with each drug, whether any controlled studies exist to
show that the drug in question saves more lives than it takes, and, if
the drug is not marketed as a "cure" for a life threatening disease,
which is typically the case, the justification for its use in
management of symptoms relative to such mortality and/or morbidity
risk by stating the *documented* population level benefit. There are
35 drugs in the list. Let’s see how you do.
that confidence in evidence based medicine is based largely on a
theoretical benefit rather than risk-adjusted health outcomes in real
people. This is roughly the tenth time or so I have published the
challenge without a single taker. If you choose to respond, you
should state the number of deaths per 1000 (or fraction thereof)
associated with each drug, whether any controlled studies exist to
show that the drug in question saves more lives than it takes, and, if
the drug is not marketed as a "cure" for a life threatening disease,
which is typically the case, the justification for its use in
management of symptoms relative to such mortality and/or morbidity
risk by stating the *documented* population level benefit. There are
35 drugs in the list. Let’s see how you do.
1. Accutane
2. Avastin
3. Calcium Channel Blockers
5. Celebrex
6. Cordarone
7. Crestor
8. Depakote
9. Erythromycin
10. Fortovase
11. Gabitril
12. Geodon
13. Halcion
14. Hismanal
15. Invirase
16. Lamictal
17. Lamisil
18. Lovanox
19. Mellaril
20. Phenergan
21. Permax
22. Prempro
23. Premphase
24. Premarin
25. Propulsid
26. Ritodrine
27. Serentil
28. Tasmar
29. Topamax
30. Trovan
31. Viagra
32. Vioxx
33. Viramune
34. Warfarin
35. Zyvox
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