Allen Steere on Seronegative Lyme or the MS version of Lyme... before Europe

[Mort Zuckerman]

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Subject: Allen Steere on Seronegative Lyme or the MS version of
Lyme... before Europe

Date: May 13, 2009 9:58 PM

I AM ANSWERING WHO DID WHAT WITH NIH GRANT MONEY

=====================================================


IDSA's Lyme diagnostic and treatment guidelines fall
flat because of stuff that happened even before Dearborn and
STEERE IN EUROPE (2 reports, Steere's "Antibodies in Europe"
and the Dressler/Steere "prospective study" of the fraudulent "ROC"
proposal with the bogus strains and recombinant OspA and B
without the lipids attached).

Lyme was known as an ASEPTIC meningitis because of the
lack of cells in the spinal fluid in 1989 (Pachner, New Great Imitator
report in the "IDSA Reviews" Supplement 6) (Bacterial meningitis
produces inflammatory cells in the CSF)

The Dressler/Steere criteria for a "clinical case" - yes, I
kid you not - of neuroborreliosis was "cells or protein in the
CSF and positive EMGs."

Cerebrospinal fluid analysis (looking for cells), and EMG
are not "clinical" criteria. In 1989 it was known by IDSA
that Lyme meningitis was mistakenly missed because it
is an ASEPTIC meningitis (low or no cells in the CSF):
http://www.actionlyme.org/IDSA_GREATIMITATOR.htm


Steere published that seronegative Lyme existed in 1991:
http://www.geocities.com/kmdickson0308/1-6.txt

Notice that he says *** half of the cases *** of the MS form
of Lyme have cells or protein in the spinal fluid (signs of
bacterial meningitis):
STEERE: “***Once present, the neurologic symptoms follow a slowly
progressive course, in some instances for 10 years or longer.*** Most
of these patients have subtle encephalopathy affecting the central
nervous system. They have memory difficulty, depression, or sleep
disturbances but no seizures, myoclonus, or changes in the level of
consciousness. They also have sensory symptoms, such as pain in the
spine, accompanied by radicular pain in the limbs or trunk, and some
have distal parethesias with intermittant tingling sensations in the
hands and feet.

"These symptoms are perilously close to those that occur in
ibromyalgia, with the chronic fatigue syndrome, or instress-induced
syndromes- conditions that are ever so much more common than tertiary
Lyme disease. How then does one identify the patient with chronic
neurologic abnormalities of Lyme disease?

"The patients in question have characteristic findings on laboratory
evaluations as follows: ***almost all were seropositive by ELISA,*half
of them had increased
cerebrospinal fluid (CSF) protein, half had evidence of slight amounts
of production of intrathecal antibody to the spirochete, and 70% had
one or more of both abnormalities.*** In addition, more than 50% had
abnormal EMGs indicating polyneuropathy affecting both proximal and
distal nerve segments, and MRI brain scans showing areas of increased
T2 signal intensity."

-------------

[Notice that that's almost like "code language" where
the perps are hinting at diagnosing "Chronic Feminozalgia”]


The point being that we have to prove they knew
they were lying all along, and we can prove that,
step by step, page by page.

This stuff about seronegative Lyme and the NO CELLS
in the MS form of Lyme preceded Dearborn and Steere
in Europe (1994 and 1992 respectively):
http://www.actionlyme.org/STEERE_IN_EUROPE.htm
http://www.actionlyme.org/DICKSON_FDA_SUBMISSION_FULL.htm
(I say FULL because the FDA left out all my data in
my data package submission to them, and the data included
the full text of Dressler/Steere).


So, you can see clearly that Steere knew there
was seronegative Lyme in 1991.

Also in 1991, Steere tested for seronegative Lyme when
he showed that his lab workers had inhaled spirochetes:
http://www.actionlyme.org/IDSA_1_COMPLICATINGVARIABLES.htm
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=1883122[uid


So, Allen Steere published about seronegative Lyme
at least twice and associated it with the non-arthritis
or the MS kind of Lyme by 1991.


DRESSLER/STEERE/DEARBORN:

Steere went to Europe in 1992 and changed the diagnostic
standard using crazy strains and recombinant antigens,
so we can throw all of Dressler/Steere and Dearborn out.

When we throw Dearborn out, we throw "Lyme Disease" out.

You can see that Lenny Sigal says “Lyme Borreliosis” is that strange,
unusual New Great Imitator, that “un-described” thing, and that
“Chronic” “Lyme Disease” was caused by hysteria, Munchausen’s and
Bored-Housewives-With-No-Sex-itis (DSM-IV: Female, with Complicated
Twilight Zone), now cured by Viagra, meaning this illegitimate
complaint – blaming the wives for their husbands’ limp winkies:
http://www.actionlyme.org/MUNCHAUSENS.htm
is no longer a legitimate Blame-The-Victim tool.

Lenny Sigal also technically avoided perjuring himself in the Railroad
case because when he was speaking about “Lyme Disease” he was not
talking about any cases of seronegative Lyme or New Great Imitator; he
was talking about “Late Lyme Arthritis In a Knee,” as isolated by the
Crazy-Steere-in-Europe-With-Funky-Strains and the Crazy “ROC” Dearborn
sh*t:
http://ourworld.compuserve.com/homepages/frankd/sigal2.htm


Very few people have Lyme arthritis in a knee, and according to
all the crooks at one time or another, is not associated with
fatigue and brain signs:
http://www.journals.uchicago.edu/doi/pdf/10.1086/432733
(That's Wormser and Klempner now saying there
are 2 different diseases. REMARKABO!!!)


When speaking to the FDA, I tried to tell them that none of the
invited
labs in 1994 agreed with Allen Steere's Dearborn proposal and that
this
*standard* was the problem
http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_11.pdf

I also hypothesized that Chronic Lyme (what *we* refer to as
chronic Lyme which is chronic neurologic Lyme, since the knee-only
people have no brain and fatigue complaints) and vaccine failure
were alike.

Chronic Lyme and vaccine failure are alike.

Steve Sheller and others at that 2001 FDA LYMErix Meeting
wanted to go with the "OspA-Causes-Arthritis" argument.


Now we know that the key to the failed HIV and tuberculosis
vaccines was Pam3Cys or OspA or the FAILED OspA vaccines, LYMErix
and ImmuLyme:
http://www.actionlyme.org/PAM3CYS_IMMUNE_SUPPRESSION.htm


But Schoen et al had access to that material (vaccine failure
is very much like chronic late neurologic Lyme) but suppressed it:
http://www.actionlyme.org/SCHOEN_INSTRUCTING_DOCS_TO_BLOW_OFF_LYMERIX_INJUREES.htm

^^^That was published in 1998, before the FDA approved
LYMErix. They had EMPIRICAL and OBJECTIVE data to
show seronegative Lyme was associated with aseptic
meningitis and they COULD HAVE HAD insight into why
Pam3Cys was such a disaster of an idea for vaccines,
since the tuberculosis vaccines all failed for the same
Pam3Cys reasons.

Persing also made a business (CORIXA) out of "What A Bad Idea
OspA Was for a Vaccine." But he modified OspA to a less
"stimulatory" (read TOXIC) antigen to sell as a class of
Vaccine Adjuvants:
http://www.actionlyme.org/STEALTH_DISABLERS.htm

PERSING RICO PATENT:
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/PTO/srchnum.htm&r=1&f=G&l=50&s1=6,800,613.PN.&OS=PN/6,800,613&RS=PN/6,800,613

"Accordingly, the methods of the invention provide a powerful and
selective approach for modulating the innate immune response pathways
in animals ***without giving rise to the toxicities often associated
with the native bacterial components that normally stimulate those
pathways."***

1995, folks.

That's when they knew LYMErix was a problem.


THEY COULD HAVE HAD THE INSIGHT into why Lyme caused
the New Great Imitators obviously, too:

Paul Duray explained it to them TWICE (1989 and 1992
at Cold Spring Harbor:
http://www.actionlyme.org/Duray.htm
http://www.actionlyme.org/CHP_9_IDSA_REVIEWS.htm
http://www.actionlyme.org/IDSA_CLINIPATH_DURAY.htm


It's not just a question (or a defense for the crooks) about
whether or not IDSA/ALDF.com had "objective data" to show that
OspA was harming people. They could have associated "Seronegative
Relapsing Neuroborrelisis" (Pat Coyle's term) with the outcomes
of OspA vaccination, like *we* did, since they obviously SAW IT:

Again, PERSING RICO PATENT:
http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6045804.PN.&OS=PN/6045804&RS=PN/6045804
"Additional uncertainty may arise if the vaccines are not completely
protective; vaccinated patients with ***multisystem complaints
characteristic of later presentations of Lyme disease may be difficult
to distinguish from patients with vaccine failure.*** Vaccine failures
have been occasionally noted in animal models (E. Fikrig et al.,
Science, 250, 553-6 (1990)), and infection with antigenically variant
strains of B. burgdorferi, which are being increasingly documented in
the U.S., might still occur.

***multisystem complaints characteristic of later
presentations of Lyme disease may be difficult to
distinguish from patients with vaccine failure.***




You can pass that around for the sake of the outside
chance that anyone from IDSA or MMI wants to do any
hard, hard, painful thinking about actual stuff.

Or even it they don’t.

It’s Suppository Psychopharmacotherapeutics for the
Do-Nothing Psychiatric Kooks on MMI and ILADS, as I call it.


Kathleen


"[Real] scientists are *fiercely* independent. That's the good
news."-- NIH's Top Fool, Anthony Fauci