Toxicity of carbon nanotubes and fullerenes

[mariolino]

Dear all,

I am writing an essay on the topic in the subject: Toxicity of carbon
nanotubes and fullerenes. I am looking for the first paper on the
research in this field, mostly because I want to know when was the
toxicity of carbon nanomaterials first researched, and who were the
pioneers.

Thank you very much in advance

mario

[Jim Logajan]

mariolino <gianmari...@gmail.com> wrote:
> I am writing an essay on the topic in the subject: Toxicity of carbon
> nanotubes and fullerenes. I am looking for the first paper on the
> research in this field, mostly because I want to know when was the
> toxicity of carbon nanomaterials first researched, and who were the
> pioneers.

If you haven't already checked it, "Nanomedicine Volume IIA:
Biocompatibility" by Robet Freitas Jr is a useful resource. He lists a
rather extensive bibliography.

But I think it is going to difficult to nail down a "first paper" on
toxicity because the definition of "carbon nanomaterials" can include
things like diamond and graphite (e.g. black lung disease.) And even if you
include only nanotubes and fullerenes, a "first" paper may deal with
toxicity on some rather narrow scope, which may not be quite what you had
in mind. Still, I suspect by including only nanotubes and fullerenes you can
probably narrow your search to papers from about 1990 and onwards, since prior
to that time there weren't known ways of producing macro quantities of either
material to perform biological toxicity studies.

[mariolino]

On Aug 10, 8:26=A0pm, Jim Logajan <Jam...@lugoj.com> wrote:

> mariolino <gianmario.sco...@gmail.com> wrote:
> > I am writing an essay on the topic in the subject: Toxicity of carbon

> > nanotubes andfullerenes. I am looking for the first paper on the

> > research in this field, mostly because I want to know when was the
> > toxicity of carbon nanomaterials first researched, and who were the
> > pioneers.
>
> If you haven't already checked it, "Nanomedicine Volume IIA:
> Biocompatibility" by Robet Freitas Jr is a useful resource. He lists a
> rather extensive bibliography.
>
> But I think it is going to difficult to nail down a "first paper" on
> toxicity because the definition of "carbon nanomaterials" can include

> things like diamond and graphite (e.g. black lung disease.) And even if y=
ou
> include only nanotubes andfullerenes, a "first" paper may deal with

> toxicity on some rather narrow scope, which may not be quite what you had

> in mind. Still, I suspect by including only nanotubes andfullerenesyou ca=
n
> probably narrow your search to papers from about 1990 and onwards, since =
prior
> to that time there weren't known ways of producing macro quantities of ei=

ther
> material to perform biological toxicity studies.

The earliest papers I could find were these:

Wagemann, K., Baselt, J.P.: Fullerenes - analysis and evaluation A
discussion paper prepared within the framework of the analysis and
evaluation of new innovative approaches to chemical fundamental
research (1992)

and

Hidetoshi Tokuyama, Shigeru Yamago, Eiichi NakamuraTakashi Shiraki and
Yukio Sugiura: Photoinduced Biochemical Activity of Fullerene
Carboxylic Acid, J. Am. Chem. Soc. 1993, 115, 7918-7919

I couldn't even reach the first one through my university, so I cited
the latter. Which, by the way, is excellent for more reasons than one.