Pathological Iron Perturbs Pregnancy

[ironjustice]

Depressed Antioxidant Status in Pregnant Women on
Iron Supplements: Pathologic and Clinical Correlates.
Biol Trace Elem Res. 2009 Oct 8.
Anetor JI, Ajose OA, Adeleke FN, Olaniyan-Taylor GO, Fasola FA.
Department of Chemical Pathology, College of Medicine,
University of Ibadan, Ibadan, Nigeria, anet...@yahoo.com.

Iron (Fe) remains a commonly prescribed supplement in pregnancy.
Its possible pathologic potential is either uncommonly considered or
ignored.
We determined the antioxidant status in pregnant women with and
without Fe supplements.
Fifty-eight apparently healthy pregnant women on Fe supplements
were selected for the study from the antenatal clinic of the
University
College Hospital, Ibadan, Nigeria.
Fifty-five aged matched pregnant women who were not on Fe from
various parishes of the Christ Apostolic Church, Ibadan (non-drug
using Christian sect) were randomly selected as controls.
Both groups were classified according to the trimesters of pregnancy.
The gestational age in both pregnant women on Fe supplements and
non-supplement pregnant women was similar.
Fruit and vegetables consumption was higher in the supplement than
in the non-supplement group (57.2% vs. 37.3%).
Anthropometric indices, weight, height, and BMI, were also similar.
But while the weight of the Fe supplement group decreased by nearly
3% in the third trimester, it increased by over 10% (p < 0.00) in the
non-supplement group in the same period.
Serum Fe level was significantly higher in the supplement than the
non-supplement group (p < 0.001). In contrast, the levels of the
antioxidants, ascorbic acid, copper (Cu), zinc (Zn), and bilirubin
were
all significantly decreased (p < 0.05, p < 0.001, p < 0.05, and p <
0.05,
respectively).
Uric acid level though also lower in the supplement group did not
reach
statistical significance (p > 0.05), while vitamin E was similar in
both
groups.
There was relative stability of all antioxidants except uric acid,
which
declined from the first to the last trimester in the non-supplement
group.
The significantly higher Fe level in the second trimester was
sustained
in the third trimester though to a lesser degree (p < 0.05) and
associated
with significant decreases in the following antioxidant levels in the
supplement group, ascorbic acid, bilirubin, Cu, and Zn (p < 0.02, p <
0.02,
p < 0.02, and p < 0.001, respectively).
Uric acid and vitamin E though lower in the supplement group were not
significantly different.
Remarkably, percentage changes between the first and third trimesters
revealed that serum Fe increased by over 116% in the Fe supplement
group, while it only increased by over 50% in the non-supplement
group.
This was associated with 23.50% decrease in ascorbate level (p <
0.003)
in the supplement group, while it decreased by only 3.70% in the
non-supplement group (p > 0.05).
Again vitamin E decreased by 17.22% in the supplement group, while
it decreased by only 7.30% in the non-supplement group during the
period.
Uric acid and bilirubin levels decreased by similar proportions during
the
period, while Zn decreased by 18.55% in the supplement group and by
14.86% in the non-supplement group.
In contrast Cu increased by 7.20% in the supplement group, while it
increased by only 2.96 in the non-supplement group.
Additionally, all the antioxidants in the supplement group except
vitamin E,
viz, ascorbic acid, bilirubin, Cu, uric acid, and Zn, were
significantly inversely
correlated with serum Fe level (r - 0.299, p < 0.05, r - 0.278, p <
0.05, r - 0.383,
p < 0.05, and r - 0.0369, p < 0.05).
These data imply markedly depressed antioxidant status in the Fe
supplement
pregnant group with attendant oxidative stress (most probably pro-
oxidant
Fe-induced).
This is associated with molecular and cellular damage as well as a
number
of pathologic and clinical correlates that underlie the exacerbation
of
morbidity and mortality in maternal and child populations,
particularly in the
developing countries.
This appears to call for serious caution and prior evaluation of
antioxidant
and Fe status and during the use of Fe supplements in pregnancy for
monitoring and prognostic purposes and to avert or ameliorate
oxidative
stress-induced pathologies in maternal and fetal systems.

PMID: 19812902

Who loves ya.
Tom

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DEAD PEOPLE WALKING
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[Mike Collins]

According to your statements that only haem iron can be absorbed to
excess the use of iron supplements would make no difference - good or
bad.

[ironjustice]

On Oct 11, 2:52 am, Mike Collins <acridiniumes...@googlemail.com>
wrote:

According to your statements that only haem iron can be absorbed to
excess the use of iron supplements would make no difference - good or
bad. <<

Your understanding of the absorption rates of iron is wrong ..
Heme iron CAUSES iron to be absorbed.
IF you eat no meat / heme iron .. then the body will NOT absorb excess
iron.
If you eat meat the heme iron CAUSES the iron supplement to NOW be
absorbed when NORMALLY it would NOT be absorbed .. UNLESS .. needed ..

Your understanding of the actions OF an ingested oxidative metal in
the stomach and inside the body is wrong ..
If an oxidizing metal is ingested the oxidation of the metal in the
stomach will destroy antioxidants ..
The antioxidants that are MISSING in the person who DID take the iron
supplements / oxidizing metal .. and those antioxidants that are NOT
missing by those who do NOT take / ingest iron supplements / oxidizing
metal.

Sooo taking / ingesting iron will destroy antioxidants in that person
who ingested the iron.

Meat CAUSES a person to absorb ALL iron ingested NOT just the meat
iron ..
Iron one would NORMALLY not absorb .. unless .. needed.

Pretty simple to understand .. for some ..

Depressed Antioxidant Status in Pregnant Women on
Iron Supplements: Pathologic and Clinical Correlates.
Biol Trace Elem Res. 2009 Oct 8.
Anetor JI, Ajose OA, Adeleke FN, Olaniyan-Taylor GO, Fasola FA.
Department of Chemical Pathology, College of Medicine,

University of Ibadan, Ibadan, Nigeria, aneto...@yahoo.com.

[Ken]

Spamming Canuck Dickhead

[ironjustice]

I think you shteating atheist btches were told ..

You seem to understand English as well as you do .. medicine ..

Isn't that right .. you little atheist .. btch ..

Fkff back to your .. blog .. btch ..