Anti-inflammatory Alpha-linolenic Omega-3 Plant Oil

[ironjustice]

Effects of alpha-linolenic acid on inflammation and oxidative stress
in the diabetic rats.
Zhang LH, Zhang W, Wei GH, Yang P, Liu J, Niu XL
Zhongguo Ying Yong Sheng Li Xue Za Zhi
2012 Jan; 28(1):64-7.

To investigate the effects of alpha-linolenic acid (ALA) on
inflammation and oxidative stress in the diabetic rats.
An experimental type 2 diabetes mellitus model was induced by feeding
male SD rats with diet of high fat for 4 weeks and then injected them
intraperitoneally with streptozocin (STZ) at 30 mg/kg.
Then the animals were randomely divided into three groups (n = 10):
control group, diabetic group and ALA group. Four weeks later, tumor
necrosis factor (TNF)-a, soluble P-selectin (sP-selectin), soluble
intercellular adhesion molecule-1 (sICAM-1), nitric oxide (NO)
production, malondialdehyde (MDA), superoxide dismutase (SOD) and
catalase (CAT) in the serum were determined.
Inflammatory agents including TNF-alpha, sP-selectin and sICAM-1
increased in diabetic rats to compare with control group.
Treatment with ALA significantly decreased TNF-alpha, sP-selectin and
slCAM-1 to compare with diabetic group. Furthermore, compared with
control group, serum MDA production increased whereas NO production,
SOD and CAT activities decreased in diabetic rats.
Treatment with ALA reduced MDA production, increased NO production,
promoted SOD and CAT activities compared with diabetic group.
These results indicate that diet rich in ALA exerted the anti-
inflammatory and anti-oxidative effects in diabetic rats, which may be
beneficial to the prevention and treatment of diabetes.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue
zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong
Sheng Li Xue Za Zhi]

-----------------

http://www.omega3oils.info/fishoilsupplements/

"Fish oils contains two types of omega 3 fatty acids, namely
eicosapentanoic acid (EPA) and docosahexanoic acid (DHA)."

"This is in contrast to plant sources of omega 3 oils that contain
alpha linolenic acid (ALA)."

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[" pill popper"]

""Fish oils contains two types of omega 3 fatty acids, namely
eicosapentanoic acid (EPA) and docosahexanoic acid (DHA)."

"This is in contrast to plant sources of omega 3 oils that contain
alpha linolenic acid (ALA).""

You are confused on this. Ala is converted into the forms found in fish
oil in our bodies. The problem is that only about 10 percent or so are
converted. It is in the form found in fish and our own bodies that are the
active agents in such studies as this one.

[ironjustice]

[ironjustice]

On Apr 18, 5:44 pm, ironjustice <ironjust...@rock.com> wrote:
Effects of alpha-linolenic acid on inflammation and oxidative stress
in the diabetic rats. <<

"Subjects with at least the median ALA intake "
"α-linolenic acid [ALA]"

Association between interaction and ratio of ω-3 and ω-6
polyunsaturated fatty acid and the metabolic syndrome in adults.
Nutrition. 2012 Mar 27.
Mirmiran P, Hosseinpour-Niazi S, Naderi Z, Bahadoran Z, Sadeghi M,
Azizi F.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition
Sciences and Food Technology, National Nutrition and Food Technology
Research Institute, Shahid Beheshti University of Medical Sciences,
Tehran, Iran.

Abstract
OBJECTIVE: To investigate the association of the intakes of ω-3
(including α-linolenic acid [ALA], eicosapentaenoic acid [EPA] plus
docosahexaenoic acid [DHA]) and ω-6 polyunsaturated fatty acids
(PUFAs), the interaction, and the ratio of these PUFAs with the
metabolic syndrome (MetS) in adults.

METHODS: This cross-sectional study was conducted in a random sample
of participants (n = 2451, 19-84 y old) in the Tehran Lipid Glucose
Study. Dietary intake was assessed using a validated semiquantitative
food-frequency questionnaire. Anthropometric characteristics, blood
pressure, and fasting plasma concentrations of glucose and lipids were
measured. The MetS was defined according to the Adult Treatment Panel
III guidelines.

RESULTS: Among the PUFAs, the ALA and ω-6 PUFA intakes were inversely
associated with the MetS. Subjects in the highest quartile of ALA and
ω-6 fatty acid intakes had a 38% (odds ratio 0.62, 95% confidence
interval 0.41-0.95) and a 0.47% (odds ratio 0.53, 95% confidence
interval 0.31-0.89) lower prevalence of MetS, respectively, compared
with those in the lowest quartile. The dietary ratio of ω-6 to ω-3
fatty acids was not associated with the MetS. When the interaction
between ALA and ω-6 fatty acid was assessed, the ALA intake was
associated with a lower prevalence of the MetS, without modification
by the ω-6 PUFA intake. Subjects with at least the median ALA intake
(1084 mg/d) had a lower prevalence of the MetS, irrespective of an ω-6
PUFA intake lower or higher than the median compared with subjects
with intakes below the median for both.

CONCLUSION: The ALA intake was inversely associated with the MetS,
irrespective of the background intake of ω-6 PUFAs, in adults.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:22459553

[trigonometry1972@gmail.com |]

I hope you are right, Mister Tom. I do rather like walnuts.
7 miles run yesterday and I am not sore today.............Trig

[montygraham]

Basically, at least some omega 3 act as "anti-essential fatty acids."
It seems that only arachidonic acid (AA) and the Mead acid (MA)can be
used for vital functions (like blood clotting). The problem with AA
is that is so reactive that it has what are often called "pro-
inflammatory" processes, and so is likely largely responsible for most
"chronic disease," especially in those who are "middle aged" or
younger. An antioxidant-rich diet can help prevent AA from becoming
too dangerous but MA appears optimal, with no threat to health.
Experiments on this subject have often depleted enough of both AA and
MA so that there may be a deficiency problem. At M.I.T. in the 1940s,
though, it was found that vitamin deficiencies could also be an
issue. I think Taka found evidence a few years back that these are
related phenomena. That is, certain vitamins may be necessary to make
precursor fatty acids into AA or MA.

[trigonometry1972@gmail.com |]

my take on fat is somewhere between your views (Ray Peat) and the
conventional.
Fish oil can help but dropping the omega 6 FA helps as well. Some
omega 6
FA source seem more benign to benefical as compared to others.
Walnuts and unheated tree nuts, yes good and sesame seeds, sunflower
seeds,
soy oil, corn oil, sunflower oil, no.

7 miles run today and I will not be sore
tommorrow............................Trig

[John H. Gohde]

On Apr 24, 2:31 am, "trigonometry1...@gmail.com |"

<trigonometry1...@gmail.com> wrote:

> 7 miles run today and I will not be sore
> tommorrow............................Trig

Thanks to astaxanthin.

That is how to avoid Alzheimer's Disease in your later years.

[Ben Stidd]

So what will you do or ingest to minimize the soreness?

[mainframetech]

Might be useful to avoid statins too.
http://www.cholesterol-and-health.org.uk/alzheimers.html
http://www.medicalnewstoday.com/articles/211339.php
http://neurobiologyoflipids.org/newsstand/2008/04/alzheimers-cholesterol-problems-with.html

It's not so much the doctors or studies that suggest it, but the
possibility that dropping cholesterol, which is used by the body to
repair and maintain communication in the nervous system, might be
doing harm to that system.

Chris

[None Given]

On Apr 24, 3:27 am, Ben Stidd <*@*.~> wrote:

I am really fit these days so its nothing I don't every day.
Start with methylsulfonylmethane in gram doses which
is pretty amazing, then I do a laundry list of stuff worth
of any denizen of sci.life-extension group. Anyway
the MSM has other benefical side effects unlike the
the conventional stuff which will ruin the stomach
and even ruin the joints. Mechanisms now being
understood if one reads the research.
Plus I make my own broth on beef hooves for vegetable soups.

7 miles at a rate of 7 to 8 minute miles. Shorter runs of
3 miles are at time run at faster rates ;-) I am not going
to bea the golden boy 20 year old but I can out run most
old guys.

I am not sore today. I'll lift weights today and dig up some
of the garden. Big risk is blisters.............lol.

Don't mock as you are a denizen of MHA. Some of its
chattering class are already gone (dead or gone quiet).

There is more on earth than what the conventional medicine
providers
"knows".....................................................Trig

[Ben Stidd]

Thanks for your reply.

That sounds very interesting.

I've never heard of MSM. I'll have to check it out.

I used to run quite a bit when I was younger, but gave it
up as life's larger demands got in the way. Now I walk
about 2 miles almost daily, swim 30 min once a week, and
do some yoga for flexibility. I'm looking to get into biking
this summer, but I'm still hunting for a decent bike.
The Schwinn I got as a gift over a decade ago is a real dog.

[Just Wondering]

This is only anecdotal, but I am totally sold on MSM. I once had a torn
rotator cuff, confirmed by a MRI and a specialist sports doctor. I was
told I needed an operation, that it would take nearly a year to fully
recuperate from the operation, and that the best I could expect was 80%
restoration of my shoulder function. A friend then told me about MSM.
I researched it on the internet, and discovered that besides a laundry
list of claimed benefits (many of which I doubted), that it was about as
nontoxic as anything could be. I figured, what do I have to lose?, and
started taking about 6 grams a day. Taking MSM was the only change I
made. In 8 weeks my rotator cuff was fully healed, with 100%
restoration of my shoulder function, and without surgery.

Again, given its nontoxicity, if you have a problem that MSM even as a
possibility of helping, why not give it a try? At worst, you will have
wasted 10 or 20 bucks.

[trigonometry1972@gmail.com |]

Pretty much my take. Heck my dose is lower and it really helps.
I run 20 miles + a week and I credit the MSM plus determination.
I know a good man with a operated on shoulder, I'll suggest MSM
and hoof broth to help.

Trig

[John H. Gohde]

On Apr 25, 3:04 am, "trigonometry1...@gmail.com |"

I do NOT take MSM personally, but I have suggested it to others.

Of course, I do NOT believe in abusing my body. My body has responded
accordingly with absolutely no joint pain.

Why men go out of their way to abuse their bodies to the point of
joint replacement and head / brain injuries is totally beyond me.

[Ben Stidd]

At what point do you view exercise becomes abusive to your body?

What exercise do you find causes head/brain injuries?

[John H. Gohde]

???

Try reading the above comments.

I happen to belong to a bare-bones health club because I think
exercise is extremely important, or let me put it this way. Exercise
is one of the few things that anyone can do to guarantee a high
quality of life.

My health club is bare-bones becuase just about the only thing you can
do there is work your butt off, besides yacking your mouth.

> What exercise do you find causes head/brain injuries?

Boxing, Pro Wrestling, Caged Strongest Man wins free for all fight
outs, and Pro American style foot ball,

[Happy Oyster]

On Wed, 25 Apr 2012 08:25:41 -0700 (PDT), "John H. Gohde"
<john.h...@gmail.com> wrote:

>Try reading the above comments.

Try a new brain.

--

http://www.twitter.com/aribertdeckers http://www.Journalist.is
http://www.kindersprechstunde.at http://www.pharmamafia.com
http://www.medulla.at http://www.ariplex.com/folia
http://www.ariplex.com/pixaloid http://www.ariplex.com/lyme/lymeblog

[John H. Gohde]

On Apr 25, 10:15 am, Happy Oyster <*@*.*> wrote:
> On Wed, 25 Apr 2012 08:25:41 -0700 (PDT), "John H. Gohde"
>

> <john.h.go...@gmail.com> wrote:
> >Try reading the above comments.
>
> Try a new brain.

I am heading out to my sweet gym, as I we speak. How is that for
using my brain?

[Ben Stidd]

I read them and re-read them.
Didn't find your explicit answers to my questions.

> I happen to belong to a bare-bones health club because I think
> exercise is extremely important, or let me put it this way. Exercise
> is one of the few things that anyone can do to guarantee a high
> quality of life.

Good for you.

I don't belong to a health club. I am my own health club.

I pay as I go to use a swimming pool at a local community college.

I own several pairs of walking shoes. I put on a pair and head out the
door almost daily. Also carry a walking stick to ward off any unleashed
dogs.

I have a 10 speed Schwinn that I ride through the neighborhood in good
weather.

I have some weights and stretch ropes in my basement that I use for
various exercises.

> My health club is bare-bones becuase just about the only thing you
> can do there is work your butt off, besides yacking your mouth.

I work my butt off too. By the way, how do you get to your health club?
What's the carbon footprint of your transportation to get there?
Try to be honest.

>> What exercise do you find causes head/brain injuries?
>
> Boxing, Pro Wrestling, Caged Strongest Man wins free for all fight
> outs, and Pro American style foot ball,

Boxing can qualify as exercise. Those who train alone with a heavy bag,
speed bag, and a jump road risk no head injury. Those who spar with
a partner wear protective head gear and rarely, if ever, receive
hard blows to the head. I knew a guy who trained that way, including a
regular sparring match. But he never boxed in either an amateur or
professional bout. He did it because he loved it as exercise.

The rest of your examples don't qualify as ordinary exercise. They're
entertainment professions.

What planet do you live on?

[Happy Oyster]

Like Tom Sawser's aunt feared: the brain is running out...

[John H. Gohde]

You have my condolences.

As far as I am concerned, the comments about MSM more than answers
your questions.

You are NOT paying be jack to be more explicit than that. In this
life, you get exactly what you deserve. :)

Have a nice life. I definitely got better ways to enjoy my life. :)

[Ben Stidd]

I didn't ask you about MSM.
I asked about exercises that abuse the body.
Your answer was wholly inadequate.

> You are NOT paying be jack to be more explicit than that. In this
> life, you get exactly what you deserve. :)

No one should pay you,
You can't answer a simple question on exercise.

> Have a nice life. I definitely got better ways to enjoy my life.

I agree.
One of those ways would be a course in remedial reading comprehension.
Another would be a course in exercise physiology.

When you get done with those two assignments, come back and maybe
you'll be allowed to sit for re-exam.

Later . . .

[John H. Gohde]

I can smell arses like you a mile away. Go waste somebodies else's
time. I have better things to do than play games with some stupid
academic snob.

[None Given]

This cross posted monster needs to go back to MHA. People are mixing
here
that shouldn't.

Lower impact exercises tend to be safer. Pretty self-evident. Running
style is
important. Running shoes in my experience are not to be trusted.
Simple
running flats and light running shoes seem safer than the so-called
trainers, YMMV. I go further and faster than......................


cut Cut CUT................Trig

[Ben Stidd]

For sure.

One of those things is making a huge carbon footprint, driving
to your health club, pretending you're in excellent physical
condition, when you're mere weakling pipsqueak, working up the type of
sweat on a treadmill that most real athletes might get mowing their lawns.

By the way, that treadmill, powered by electricity, makes a carbon
footprint as well.

Another is knowing jack about exercise physiology, along with confusing
professional athletic performance in the entertainment industry for
ordinary exercise.

Your failure to defend your claims, under the guise of running away
for 'better things to do,' is noted. It comports with the rest of your
highly putrid existence.

You're welcome to come back for more anytime you feel the need for a
good ass-whoopin'.

[John H. Gohde]

Bicycling is NOT a load bearing exercise. Therefore, I do NOT bike or
otherwise waste my limited time.

> I have some weights and stretch ropes in my basement that I use for
> various exercises.
>
> > My health club is bare-bones becuase just about the only thing you
> > can do there is work your butt off, besides yacking your mouth.
>
> I work my butt off too. By the way, how do you get to your health club?
> What's the carbon footprint of your transportation to get there?

I walk to get there. Can you visualize just how close my public gym
is to my residence?

> Try to be honest.
>
> >> What exercise do you find causes head/brain injuries?
>
> > Boxing, Pro Wrestling, Caged Strongest Man wins free for all fight
> > outs, and Pro American style foot ball,
>
> Boxing can qualify as exercise. Those who train alone with a heavy bag,
> speed bag, and a jump road risk no head injury. Those who spar with
> a partner wear protective head gear and rarely, if ever, receive
> hard blows to the head. I knew a guy who trained that way, including a
> regular sparring match. But he never boxed in either an amateur or
> professional bout. He did it because he loved it as exercise.
>
> The rest of your examples don't qualify as ordinary exercise. They're
> entertainment professions.

So, you are trying to tell me that none of these pursuits require
exercise? Surely, you are NOT claiming that professional American
foot ball players do NOT have to participate in an extremely rigorous
exercise program?

Surely, you have heard of teenage American high school football
players dying during training and ending up with brains injuries as a
result of playing a stupid game?

Anyway you slice it, men cannot self-destruct fast enough whereas
women almost never do.

> What planet do you live on?

Take a guess. WRONG answer, dumb ... dumb. I live in reality, unlike
you.

[Steven Bornfeld]

On 4/25/2012 7:21 AM, John H. Gohde wrote:

Sounds as if it is chemically similar to DMSO (dimethyl sulfoxide) which
had a brief vogue for musculoskeletal pain maybe 20 years ago. What I
remember is that it was an orphan drug; was used to treat interstitial
cystitis; that medical grade was hard to get, so many people were buying
it as solvent grade which could have been adulterated; that it was
absorbed through the skin and tended to cause absorption of whatever was
dissolved in it; and that the main use was cataract formation.
MSM is taken orally? I'll look into it.

>
> Of course, I do NOT believe in abusing my body. My body has responded
> accordingly with absolutely no joint pain.
>
> Why men go out of their way to abuse their bodies to the point of
> joint replacement and head / brain injuries is totally beyond me.

Well, in the states, some of them are going for the big bucks (boxing,
American football)--you are in the UK, right?
Most of them of course never get the big bucks. Sucker bet in any case.

Steve


--
Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001

[John H. Gohde]

I mostly believe in load bearing and body building exercise. You
never know when you are going to get the opportunity to clock some
numskull SCIENCE person.

Nevertheless, aerobic exercise promotes circulation and helps to
prevent Alzheimer's Disease. Ergo, I need to take aerobic exercise a
little bit more seriously.

One thing for sure is that long-distance running is passé, and not at
all recommended for good long term health. It is what I would consider
abusive to your body and, therefore, counter productive.

[John H. Gohde]

> I mostly believe in load bearing and body building exercise.  You
> never know when you are going to get the opportunity to clock some
> numskull SCIENCE person.

Performing calf raises standing up with a very heavy weight rattles
your entire skeleton in one movement for an excellent bone strength
building maneuver.

[Ben Stidd]

On 4/26/2012 8:43 AM, John H. Gohde wrote:

> I live in reality

You live on planet Bizarro.

[Ben Stidd]

On 4/26/2012 11:31 AM, John H. Gohde wrote:
> I mostly believe in load bearing and body building exercise.

Too bad you don't believe in brain exercise.

Your display of brain power in this ng is nil.

[Ben Stidd]

On 4/26/2012 11:36 AM, John H. Gohde wrote:
> Performing calf raises standing up with a very heavy weight rattles
> your entire skeleton

Go do an exercise that rattles your brain.

It needs some major rattling.

[John H. Gohde]

A clear case of the pot calling the kettle black.

You have my condolences for just now finding out just how really
stupid you really are. Proof once again that a science degree does
NOT prevent stupidity.

[Happy Oyster]

On Thu, 26 Apr 2012 05:43:01 -0700 (PDT), "John H. Gohde"
<john.h...@gmail.com> wrote:

>I live in reality,

Nice name for a cage.

[Happy Oyster]

On Thu, 26 Apr 2012 08:31:03 -0700 (PDT), "John H. Gohde"
<john.h...@gmail.com> wrote:

>Nevertheless, aerobic exercise promotes circulation and helps to
>prevent Alzheimer's Disease.

No proof for that.

And, as a counter-proof: if John H. Gohde made all the exercises, why
didn't he make it?

[John H. Gohde]

On Apr 26, 1:39 pm, Happy Oyster <*@*.*> wrote:
> On Thu, 26 Apr 2012 05:43:01 -0700 (PDT), "John H. Gohde"
>

> <john.h.go...@gmail.com> wrote:
> >I live in reality,
>
> Nice name for a cage.
>
> --
>
> http://www.twitter.com/aribertdeckers http://www.Journalist.is     http://www.kindersprechstunde.at       http://www.pharmamafia.comhttp://www.medulla.at                 http://www.ariplex.com/foliahttp://www.ariplex.com/pixaloid       http://www.ariplex.com/lyme/lymeblog

Happy Oyster?

Ha, ... hah, Ha!

What? Had a little accident in your pants, Happy Oyster?

[trigonometry1972@gmail.com |]

On Apr 26, 7:27 am, Steven Bornfeld <bornfeldm...@dentaltwins.com>
wrote:

Really? Have you been under a rock for the last 50 years?

On Apr 26, 7:27 am, Steven Bornfeld <bornfeldm...@dentaltwins.com>
wrote:

> On 4/25/2012 7:21 AM, John H. Gohde wrote:
>
>
>
>
>
>
>
>
>
> > On Apr 25, 3:04 am, "trigonometry1...@gmail.com |"
> > <trigonometry1...@gmail.com> wrote:

Really? You're going to look into?


First, I recall using DMSO on horses decades ago. Granted it
was spec grade not solvent grade :-) And MSM a couple decades ago
as well. It has the rep of delaying cancer in our 4 hooved friends.
I could suggest the mechanism but that is well not for you.
Look at the Vet's version of the Merck and you see it is
an oxygen derived free radical scavenger amd osmotic
diuretic.

MSM is dimethyl sulfone (IUPAC) it has another oxygen on the
molecule.
With simple molecules like
this one more oxygen makes a big difference. Don't
conflate the two while related they different ;-)

The solvent grade of DMSO isn't adulterated it's contaminated due
to too little distillation. You are already loading your words and
putting up blinders.

MSM never went away. It works for what it works for.
Quite effective for seasonal allergies by the way besides
its other benefits. Granted YMMV and I do other things.

The cataract concern on DMSO is found in high dose in vitro studies
not
in vivo human (some animal though) that I can see. Or maybe we can
discuss mercury and
amalgams again ;-). Anyway, you quackwatch types have caused
more cataracts than DMSO has caused cataracts. You've opposed
the use of quercetin at least some of you though I suppose not
you personally (I didn't check your history). Quercetin blocks
DMSO cataracts.

Do a PubMed search with the word methylsulfonylmethane.

Better yet buy a bottle a take it. It's safe compared to Aleve and
Tylenol.

1. J Sports Med Phys Fitness. 2012 Apr;52(2):170-4.

Effect of methylsulfonylmethane supplementation on exercise - Induced
muscle
damage and total antioxidant capacity.

Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B.

Islamic Azad University-Ardabil branch, Ardabil, Iran -
bnakh...@iauardabil.ac.ir.

AIM: The aim of this study was to evaluate effect of 10-day
methylsulfonylmethane
(MSM) supplementation on exercise-induced muscle damage.
METHODS: Eighteen healthy, non-smoking, active young men were
recruited to
participate in this study. Participants were randomized in a double-
blind
placebo-controlled fashion into two groups: MSM (M) (N.=9) and placebo
(P)
(N.=9). Subjects consumed daily either placebo (200 mL water) or MSM
supplement
(50 mg/kg MSM in 200 mL water) for 10 days. Afterward, participants
ran 14 km.
Blood samples were taken before supplementation, before exercise,
immediately, 30
min, 2, 24 and 48 h after exercise.
RESULTS: CK and bilirubin significantly increased in P group 24 h
after exercise
compared to M group (P=0.041 and P=0.002, respectively). TAC increased
immediately post, 30 min, 2 and 24 h after exercise just in M group
(P<0.05). TAC
showed significant increase in M group 2 and 24 h after exercise
compared to P
group (P=0.014 and P=0.033, respectively).
CONCLUSION: It seems that 10-day supplementation with MSM has allowed
to decrease
muscle damage via effect on antioxidant capacity.

PMID: 22525653 [PubMed - in process]


1. Life Sci. 2011 Sep 26;89(13-14):473-8. Epub 2011 Jul 28.

Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of
IL-6 and IL-8
expression in the human chondrocyte cell line C-28/I2.

Kloesch B, Liszt M, Broell J, Steiner G.

Ludwig Boltzmann Institute for Rheumatology and Balneology,
Kurbadstrasse 14,
1100 Vienna, Austria. burkhard...@gmx.at

AIMS: Reactive oxygen species (ROS) are highly diffusable and reactive
molecules
which modulate gene transcription, particularly of pro-inflammatory
cytokines
which play a crucial role in the nascency and progression of chronic
inflammatory
diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA).
Since thiols
could be potent inhibitors of the production of cytokines, the effects
of
dimethyl sulphoxide (DMSO) and dimethyl sulphone (DMS) on constitutive
and
IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell
line C-28/I2
were evaluated.
MAIN METHODS: C-28/I2 cells were incubated for 12h with different
concentrations
of DMSO or DMS. The secretion of IL-6 and IL-8 was quantified by
enzyme-linked
immunosorbent assays (ELISAs). The impact of DMSO and DMS on the
regulation of
p38 and ERK1/2 mitogen-activated protein kinases (MAPKs) was confirmed
by Western
blot experiments. Furthermore, C-28/I2 cells were stimulated with
IL-1β in the
absence or presence of DMSO and DMS and IL-6 and IL-8 expression was
quantified
by ELISAs and quantitative real-time polymerase chain reaction (qRT-
PCR).
KEY FINDINGS: C-28/I2 cells constitutively expressed large quantities
of IL-6 and
IL-8. Long-term exposure of cells to DMSO (1%) or DMS (100mM) led to a
dramatic
downregulation of IL-6 and IL-8 expression which was accompanied by
the
deactivation of ERK1/2. Both substances also blocked IL-1β-induced
IL-6 and IL-8
expression.
SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS
represent
strong anti-inflammatory properties by blocking constitutive as well
as
IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell
line
C-28/I2.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID: 21821055 [PubMed - indexed for MEDLINE]

[trigonometry1972@gmail.com |]

On Apr 26, 5:41 pm, "trigonometry1...@gmail.com |"

> bnakhos...@iauardabil.ac.ir.

> 1100 Vienna, Austria. burkhard.kloe...@gmx.at ...
>
> read more »

Still thinking there Steven? Still looking into it?
Mumbling about "science based medicine"?

mercury vapor is good.........................Trig

[John H. Gohde]

I re-read this entire thread and used the info to add Synonyms to my
custom search engine. When I am done with this process, it will be
just like PubMed, but a lot better and easier to use.

[John H. Gohde]

On Apr 26, 3:28 am, Ben Stidd <*@*.~> wrote:
> Your failure to defend your claims, under the guise of running away
> for 'better things to do,' is noted. It comports with the rest of your
> highly putrid existence.

Hello Arse!

I suggest that you re-read, or perhaps read for the first time, the
entire THREAD. I never used the word exercise. You are the ARSE who
added the word exercise to my original comment. :)

[John H. Gohde]

This makes Ben Stidd either a total moron incapable of reading the
printed word in English or a liar.

Personally, I vote for liar.

Everyone of you SCIENCE people on these ngs are nothing, but proven
liars who, thusly, should be exterminated for the betterment of
society as a whole, or at least spend the rest of your miserable
wrecked lives rotting in some prison for vaccine crimes against
humanity . :)

[Ben]

On 4/29/2012 6:32 AM, John H. Gohde wrote:
> Everyone of you SCIENCE people on these ngs are nothing, but proven
> liars who, thusly, should be exterminated for the betterment of
> society as a whole, or at least spend the rest of your miserable
> wrecked lives rotting in some prison for vaccine crimes against
> humanity . :)

You really should get out of your room more often.

[John H. Gohde]

Hello Ben Stidd, the liar.

[Benrus]

On 4/29/2012 11:52 AM, John H. Gohde wrote:
> Hello Ben

Don't forget to take your meds today.

[Robert Miles]

On 4/18/2012 7:52 PM, " pill popper" wrote:
> ""Fish oils contains two types of omega 3 fatty acids, namely
> eicosapentanoic acid (EPA) and docosahexanoic acid (DHA)."
>
> "This is in contrast to plant sources of omega 3 oils that contain
> alpha linolenic acid (ALA).""
>
> You are confused on this. Ala is converted into the forms found in fish
> oil in our bodies. The problem is that only about 10 percent or so are
> converted. It is in the form found in fish and our own bodies that are the
> active agents in such studies as this one.

I read differently - only under 1% of the ALA is converted to EPA
or DHA in our bodies.

However, in cattle, the percentage is much higher. Therefore,
grass-fed beef is a good source of EPA and DHA, since grass gives
them an adequate supply of ALA. The cheaper and more commom
grain-fed beef isn't, since grain doesn't contain much ALA.