Jason,
The cause of many childhood autism spectrum disorders (ASD) have
been found. Andrew Wakefield, who was vilified by the drug companies
has since been found to have been right. There are many studies that
have shown that his results were right in finding the MMR vaccine was
the cause of difficulties in the intestines which entered the
bloodstream and caused trouble in the brain for vaccinated children.
I will put a list of the studies that either duplicated Wakefield's
results, or agreed with his results.
If you want to see the corrective treatment for ASD and related
diseases, there is a website for Dr. Natasha Campbell-McBride, who was
a neurosurgeon and when her son got Autism (ASD) she studied and
became a pediatrician and found a diet that would clean up his 'gut'
and correct his autism. She now uses her method successfully on many
other children. Of course, the drug companies hope she will die,
because they sell really costly medicines for the disorder that mostly
do nothing.
http://www.gaps.me/preview/?page_id=35
While the polio vaccine has done amazing things when it was new,
now the vacine is like many other vaccines in that it was made to be
very weak and needs more than one shot to make it work (booster). All
for the drug industry profits. Soon they will come out with a vaccine
for flaky dandruff and the government will make it mandatory.
Chris
Here's the list of studies that agree or support Wakefield:
The following peer-reviewed papers support the findings of the
original work by Wakefield and colleagues at the Royal Free Hospital
in the UK:
1) Furlano R, Anthony A, Day R, Brown A, Mc Garvey L, Thomson M, et
al. Colonic CD8 and T cell filtration with epithelial damage in
children with autism. J Pediatr 2001;138:366-72.
2) Torrente F., Machado N., Perez-Machado M., Furlano R., Thomson M.,
Davies S., Wakefield AJ, Walker-Smith JA, Murch SH. Enteropathy with T
cell infiltration and epithelial IgG deposition in autism. Molecular
Psychiatry. 2002;7:375-382.
3) Ashwood P, Murch SH, Anthony A, Hayes C, Machado MP, Torrente F,
Thomson MA, Heuschkel R, Wakefield AJ., Mucosal and peripheral blood
lymphocyte cytokine profiles in children with regressive autism and
gastrointestinal symptoms: Mucosal immune activation and reduced
counter regulatory interleukin-10. Gastroenterol. 2002;122
(Suppl):A617
4) Ashwood P, Anthony A, Torrente F, Wakefield AJ. Spontaneous mucosal
lymphocyte cytokine profiles in children with autism and
gastrointestinal symptoms: mucosal immune activation and reduced
counter regulatory interleukin-10. J Clin Immunol. 2004;24(6):664-73.
5) Wakefield AJ., Puleston J. Montgomery SM., Anthony A., O’Leary
J.J., Murch SH Entero-colonic encephalopathy, autism and opioid
receptor ligands. Alimentary Pharmacology & Therapeutics.
2002;16:663-674
6) Wakefield AJ. The Gut-Brain Axis in Childhood developmental
Disorders. Journal of Pediatric Gastroenterology and Nutrition.
2002;34:S14-S17
7) Uhlmann V, Martin CM, Sheils O, Pilkington L, Silva I, Killalea A,
Murch SH, Wakefield AJ, O’Leary JJ., Potential viral pathogenic
mechanism for new variant inflammatory bowel disease. Molecular
Pathology 2002;55:84-90
8) Ashwood P, Anthony A, Pellicer AA, Torrente F, Wakefield AJ.
Intestinal lymphocyte populations in children with regressive autism:
evidence for extensive mucosal immunopathology. Journal of Clinical
Immunology, 2003;23:504-517.
9) Torrente F, Anthony A, Heuschkel RB, Thomson MA, Ashwood P, Murch
SH. Focal-enhanced gastritis in regressive autism with features
distinct from Crohn's and Helicobacter pylori gastritis. Am J
Gastroenterol. 2004;99:598-605
10) Ashwood P, Wakefield AJ. Immune activation of peripheral blood and
mucosal CD3+ lymphocyte cytokine profiles in children with autism and
gastrointestinal symptoms. J Neuroimmunol. 2006;173(1-2):126-34.
11) Wakefield AJ, Ashwood P, Limb K, Anthony A. The significance of
ileo-colonic lymphoid nodular hyperplasia in children with autistic
spectrum disorder. Eur J Gastroenterol Hepatol. 2005 Aug;17(8):827-36.
The following two peer-reviewed papers from the Royal Free Hospital in
the UK were withdrawn for political reasons, but the science remains
valid and relevant
1) Wakefield AJ, Murch SM, Anthony A et al., Ileal- lymphoid- nodular
Hyperplasia, Non- specific Colitis, and Pervasive Developmental
Disorder in Children, The Lancet, 1998, 351(9103): 637– 41.
2) Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies
S, Walker-Smith JA. Enterocolitis in children with developmental
disorder. American Journal of Gastroenterology 2000;95:2285-2295.
The following peer-reviewed papers duplicate Dr. Wakefield’s original
findings in five additional countries, including the US, Italy,
Venezuela, Canada and Poland:
1) Gonzalez, L. et al., Endoscopic and Histological Characteristics
of the Digestive Mucosa in Autistic Children with gastro-Intestinal
Symptoms. Arch Venez Pueric Pediatr, 2005;69:19-25.
2) Balzola, F., et al., Panenteric IBD-like disease in a patient with
regressive autism shown for the first time by wireless capsule
enteroscopy: Another piece in the jig-saw of the gut-brain syndrome?
American Journal of Gastroenterology, 2005. 100(4): p. 979- 981.
3) Balzola F et al . Autistic enterocolitis: confirmation of a new
inflammatory bowel disease in an Italian cohort of patients.
Gastroenterology 2005;128(Suppl. 2);A-303.
4) Krigsman A, Boris M, Goldblatt A, Stott C. Clinical Presentation
and Histologic Findings at Ileocolonoscopy in Children with Autistic
Spectrum Disorder and Chronic Gastrointestinal Symptoms. Autism
Insights. 2009;1:1–11.
5) Horvath K., Papadimitriou J.C., Rabsztyn A., Drachenberg C., Tildon
J.T. 1999. Gastrointestinal abnormalities in children with autism. J.
Pediatrics 135: 559-563.
6) Sabra S, Bellanti JA, Colon AR. Ileal lymphoid hyperplasia, non-
specific colitis and pervasive developmental disorder in children. The
Lancet 1998;352:234-5.
7) Sabra A, Hartman D, Zeligs BJ et al., Linkage of ileal-lymphoid-
nodular hyperplasia (ILNH), food allergy and CNS developmental
abnormalities: evidence for a non-IgE association, Ann Allergy Asthma
Immunol, 1999;82:8
8) Galiatsatos P, Gologan A, Lamoureux E, Autistic enterocolitis: Fact
or fiction? Can J Gastroenterol. 2009:23:95-98
9) Jarocka-Cyrta et al. Brief report: eosinophilic esophagitis as a
cause of feeding problems in an autistic boy. The first reported
case.J. Aut. Dev. Disord. Online July 10, 2010
The following articles support the importance of recognizing and
treating gastrointestinal symptoms in autistic children:
1) Buie T, et al. Pediatrics. 2010 Jan;125 Suppl 1:S19-29.
Recommendations for evaluation and treatment of common
gastrointestinal problems in children with ASDs.
2) Buie T, et al. Pediatrics. 2010 Jan;125 Suppl 1:S1-18.
Evaluation, diagnosis, and treatment of gastrointestinal disorders in
individuals with ASDs: a consensus report.
The following peer-reviewed papers provide further support for
gastrointestinal disturbances involving the immune system in autism.
1) Jyonouchi H., Sun S., Lee H. 2001. Proinflammatory and regulatory
cytokine production associated with innate and adaptive immune
responses in children with autism spectrum disorders and developmental
regression. J. Neuroimmunol. 120(1-2):170-9
2) Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier B. Dysregulated Innate
Immune Responses in Young Children with Autism Spectrum Disorders:
Their Relationship to Gastrointestinal Symptoms and Dietary
Intervention. Neuropsychobiology. 2005;28:5177-85
3) Jyonouchi H, Geng L, Ruby A, Reddy C, Zimmerman-Bier B. Evaluation
of an association between gastrointestinal symptoms and cytokine
production against common dietary proteins in children with autism
spectrum disorders. J Pediatr.2005;146(5):605-10.
4) Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with
inflammatory responses and cytokine production against common dietary
proteins in patients with autism spectrum disorder.
Neuropsychobiology. 2002;46(2):76-84.
5) Vojdani A, O'Bryan T, Green JA, McCandless J, Woeller KN, Vojdani
E, Nourian AA, Cooper EL. Immune response to dietary proteins, gliadin
and cerebellar peptides in children with autism. Nutr. Neurosci.
2004;7:151-61.
6) Whiteley P, Haracopos D, Knivsberg AM, Reichelt KL, Parlar S,
Jacobsen J, Seim A, Pedersen L, Schondel M, Shattock P. The ScanBrit
randomised, controlled, single-blind study of a gluten- and casein-
free dietary intervention for children with autism spectrum disorders.
Nutr Neurosci. 2010;13(2):87-100.
7) Knivsberg AM, Reichelt KL, Høien T, Nødland M. A randomised,
controlled study of dietary intervention in autistic syndromes. Nutr
Neurosci. 2002;5(4):251-61.
8) Balzola F, et al. Beneficial behavioural effects of IBD therapy and
gluten/casein-free diet in an Italian cohort of patients with autistic
enterocolitis followed over one year. Gastroenterology 2008;4:S1364.
9) Valicenti-McDermott M., McVicar K., Rapin I., et al., Frequency of
Gastrointestinal Symptoms in Children with Autistic Spectrum Disorders
and Association with Family History of Autoimmune Disease.
Developmental and Behavioral Pediatrics. 2006;27:128-136
10) Chen B, Girgis S, El-Matary W. Childhood Autism and Eosinophilic
Colitis. Digestion 2010;18:127-129
11) Sandler R, Finegold SM., Bolte ER., et al. Short-term benefit from
oral vancomycin treatment of regressive-onset autism. J Child Neurol.
2000;15:429-435