Antioxidant activity of NSAID hydroxamic acids.
Acta Pharm. 2009 Jun 1;59(2):235-242.
Končič MZ, Rajič Z, Petrič N, Zorc B.
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb,
Croatia.
In the present study, seven hydroxamic acid derivatives of
nonsteroidal
anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen,
indomethacin and diclofenac) were found to possess significant
antioxidant,
radical scavenging and metal chelating activities.
The most active antioxidant and radical scavenger was N-
methylhydroxamic
acid of diclofenac (ANT = 88.0% and EC50 = 60.1 mug mL-1).
The activity of the standard substance, butylated hydroxyanisole, in
the two
assays was ANT = 86.9% and EC50 = 18.8 mug mL-1, respectively.
Ibuproxam was the strongest iron chelator among investigated
hydroxamic acids
(EC50 = 255.6 mug mL-1), yet significantly weaker than the standard
substance,
EDTA (EC50 = 29.1 mug mL-1).
It seems that different mechanism is involved in metal chelating
activity than in
antioxidant and radical scavenging activity.
Antioxidant and radical scavenging activities may be connected with
conjugation
of the nitrogen lone electron pair with the carbonyl group.
On the other hand, more hydrophilic substances tend to be better iron
chelators.
PMID: 19564147
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
>"Metal chelating activities"
>"Strongest iron chelator"
>"Metal chelating activity"
>"Iron chelators"
So what!?
--
"Der K�lner Dom ist gro� und gothisch,
der Knochenkult ist religiotisch."
I'm sorry predators cannot be heard over the sound of how
awesome I am.
"Metal chelating activities"
"Strongest iron chelator"
"Metal chelating activity"
"Iron chelators"
Antioxidant activity of NSAID hydroxamic acids.
>I'm sorry predators cannot be heard over the sound of how
>awesome I am.
That is what psychiatrists call a record disc with a crack.
I'm sorry predators cannot be heard over the sound of how
awesome I am.
"Metal chelating activities"
"Strongest iron chelator"
"Metal chelating activity"
"Iron chelators"
Antioxidant activity of NSAID hydroxamic acids.
Acta Pharm. 2009 Jun 1;59(2):235-242.
Končič MZ, Rajič Z, Petrič N, Zorc B.
Hmmm, a couple of those are related to liver failure in large doses.
CCould this described action cause it?
>I'm sorry predators cannot be heard over the sound of how
>awesome I am.
>
>
>"Metal chelating activities"
Chelation treatment is dangerous.
--
" Ich glaub, ans gro�e Weltgericht
glaubt selbst manch Pfarrer heute nicht."
Stay in your mama's
basement with your gay porn and cum drenched keyboard. You are an
illterate spamming tosser with no hope of redemption. You would have
more luck of finding redemption with Allah. You use the internet as
your personal weapon of mass destruction. You copy and paste research
that is frequently flawed. The research often does NOT relate to the
subject line. Just because a piece of research is found on PubMedI
does not mean it is not flawed. I will always cut your spam when
posting a reply to your tripe. At first I found it hillarious to see
someone so delusional, illiterate (that was sad), and a veiled
attempt
to extrapolate a conclusion from research that even the primary
researchers had no intention of doing. Tom you think you are God sent
(a delusion), intelligent (another delusion) and you think people
respect your opinion (another delusion). Three strikes your out). So
fuck off Tom.
I'm sorry predators cannot be heard over the sound of how
awesome I am.
"Metal chelating activities"
>On Jul 4, 10:22�am, Happy Oyster <happy.oys...@ariplex.com> wrote:
>> On Fri, 3 Jul 2009 16:15:39 -0700 (PDT), ironjustice <ironjust...@rock.com>
>> wrote:
>>
>> >I'm sorry predators cannot be heard over the sound of how
>> >awesome I am.
>>
>> >"Metal chelating activities"
>>
>> Chelation treatment is dangerous.
>>
>> --
>> � � � � � � � �" Ich glaub, ans gro�e Weltgericht
>> � � � � � � � glaubt selbst manch Pfarrer heute nicht."
>>
>> � � � � � � � � � � �http://www.reimbibel.de
>
>Stay in your mama's
>basement with your gay porn and cum drenched keyboard. You are an
>illterate spamming tosser with no hope of redemption. You would have
>more luck of finding redemption with Allah. You use the internet as
>your personal weapon of mass destruction. You copy and paste research
>that is frequently flawed. The research often does NOT relate to the
>subject line. Just because a piece of research is found on PubMedI
>does not mean it is not flawed. I will always cut your spam when
>posting a reply to your tripe. At first I found it hillarious to see
>someone so delusional, illiterate (that was sad), and a veiled
>attempt
>to extrapolate a conclusion from research that even the primary
>researchers had no intention of doing. Tom you think you are God sent
>(a delusion), intelligent (another delusion) and you think people
>respect your opinion (another delusion). Three strikes your out). So
>fuck off Tom.
That's clearly a case for "use your spectacles, if you are shortsighted!".
--
" Ich glaub, ans gro�e Weltgericht
I'm sorry predators cannot be heard over the sound of how
awesome I am.
"Metal chelating activities"
>I'm sorry predators cannot be heard over the sound of how
>awesome I am.
And so ge goes on, ad nauseam - which he already must have reached...
--
Vollalternative Schmerzbehandlung
I'm sorry predators cannot be heard over the sound of how
awesome I am.
>I'm sorry predators cannot be heard over the sound of how
>awesome I am.
And there goes in circles...
--
Der Fall Fischer/Stemmann
http://www.ariplex.com/ama/ama_stem.htm
I'm sorry predators cannot be heard over the sound of how
awesome I am.
>I'm sorry predators cannot be heard over the sound of how
>awesome I am.
His diet seems to have a terrible influence on his brain...
--
Hom�opathisches Akutmittel bei Asthma
I'm sorry predators cannot be heard over the sound of how
awesome I am.
I'm sorry predators cannot be heard over the sound of how
awesome I am.
"Metal chelating activities"
"Strongest iron chelator"
"Metal chelating activity"
"Iron chelators"
Antioxidant activity of NSAID hydroxamic acids.
Acta Pharm. 2009 Jun 1;59(2):235-242.
Končič MZ, Rajič Z, Petrič N, Zorc B.
Obsessions are repeated, persistent and unwanted ideas, thoughts,
images or impulses that you have involuntarily and that seem to make
no sense. These obsessions typically intrude when you're trying to
think of or do other things.
Compulsions are repetitive behaviors that you feel driven to perform.
These repetitive behaviors are meant to prevent or reduce anxiety or
distress related to your obsessions. You may also make up rules or
rituals to follow that help control the anxiety you feel when having
obsessive thoughts.
BTW----Stay in your mama's
basement with your gay porn and cum drenched keyboard. You are an
illterate spamming tosser with no hope of redemption. You would have
more luck of finding redemption with Allah. You use the internet as
your personal weapon of mass destruction. You copy and paste research
that is frequently flawed. The research often does NOT relate to the
subject line. Just because a piece of research is found on PubMedI
does not mean it is not flawed. I will always cut your spam when
posting a reply to your tripe. At first I found it hillarious to see
someone so delusional, illiterate (that was sad), and a veiled
attempt
to extrapolate a conclusion from research that even the primary
researchers had no intention of doing. Tom you think you are God sent
(a delusion), intelligent (another delusion) and you think people
respect your opinion (another delusion). Three strikes your out).
>"Metal chelating activities"
Chelating is harmful.
I must be stupid I have no understanding of what you just wrote...my
Dr. told me I'm slighty anemic does that affect pain or pain meds?